Institutional Repository of Key Laboratory of Mental Health, CAS
| Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression | |
Li, Mingzhen1,2; Teng, Huajing3; Sun, Guangqiang1; Zhao, Jingjie1,6; Fan, Min2; Zhao, Zhenlin2; Zhou, JianJun4; Zhao, Mei1,5
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| Corresponding Author | Zhou, JianJun(zhoujj_2000@aliyun.com) ; Zhao, Mei(zhaomei@psych.ac.cn) |
| Abstract | Corticosterone (CORT), the main HPA-axis glucocorticoid hormone in rodents, is involved in the regulation of animal stress responses. However, the neural mechanisms underlying the effects of corticosteroids on depression are yet to be elucidated. We found that fluoxetine reversed neurite growth inhibition induced by COAT in PC12 cells, a widely used model system for neurobiological and neurotoxicological studies. Transcriptome profiling showed that 1,609 genes were up-regulated, whereas 1,764 genes were down-regulated significantly in the CORT group in comparison with the Control group. Of them, the expression of 589 DEGs was reversed after fluoxetine treatment, and genes related to cell morphogenesis, neurite growth, and immune function were involved in the neuroprotective effect of fluoxetine against CORT. Furthermore, expression of neurite growth-related genes, such as such as Calpain 2 (Capn2), vesicle-associated membrane protein 7 (Vamp7) and C-type natriuretic peptide (Cnp), altered in a brain region- or treatment-specific manner in the animal models of depression. Therefore, the interaction between stress, glucocorticoids, and neurite growth inhibition may be a candidate pathophysiology underlying major depressive disorder (MDD), and the identification of Capn2, Vamp7 and Cop might provide insight into treatment of MDD. |
| Keyword | Calpain 2 (Capn2) Vesicle-associated membrane protein 7 (Vamp7) C-type natriuretic peptide (Cnp) PC12 cells Animal model of depression |
| 2019-06-01 | |
| Language | 英语 |
| DOI | 10.1016/j.psychres.2019.04.017 |
| Source Publication | PSYCHIATRY RESEARCH
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| ISSN | 0165-1781 |
| Volume | 276Pages:79-86 |
| Indexed By | SCI ; SCI |
| Funding Project | National Natural Science Foundation of China[91132728] ; National Natural Science Foundation of China[31741062] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine[QN2018-33] ; Beijing Natural Science Foundation[7172063] ; Beijing Health System Training Program for High Level Technique Talents[2014-3-001] |
| Publisher | ELSEVIER IRELAND LTD |
| WOS Keyword | NATRIURETIC-PEPTIDE ; PREFRONTAL CORTEX ; PC12 CELLS ; STRESS ; EXPRESSION ; DIFFERENTIATION ; LOCALIZATION ; OUTGROWTH ; PROTEIN ; TOPHAT |
| WOS Research Area | Psychiatry |
| WOS Subject | Psychiatry |
| WOS ID | WOS:000471358800012 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/29143 |
| Collection | 中国科学院心理健康重点实验室 |
| Corresponding Author | Zhou, JianJun; Zhao, Mei |
| Affiliation | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Shenzhen Ruipuxun Acad Stem Cell & Regenerat Med, Shenzhen 518035, Peoples R China 3.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China 4.Tongji Univ, Canc Stem Cell Inst, East Hosp, Res Ctr Translat Med,Sch Med, Shanghai 200120, Peoples R China 5.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 6.Capital Med Univ, Beijing Friendship Hosp, Beijing 100050, Peoples R China |
| First Author Affilication | Key Laboratory of Mental Health, CAS |
| Corresponding Author Affilication | Key Laboratory of Mental Health, CAS |
| Recommended Citation GB/T 7714 | Li, Mingzhen,Teng, Huajing,Sun, Guangqiang,et al. Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression[J]. PSYCHIATRY RESEARCH,2019,276:79-86. |
| APA | Li, Mingzhen.,Teng, Huajing.,Sun, Guangqiang.,Zhao, Jingjie.,Fan, Min.,...&Zhao, Mei.(2019).Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression.PSYCHIATRY RESEARCH,276,79-86. |
| MLA | Li, Mingzhen,et al."Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression".PSYCHIATRY RESEARCH 276(2019):79-86. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Transcriptome Profil（803KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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