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Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice
Lu-lu Yu; Xue-yi Wang; Mei Zhao; Yu Liu; Yan-qin Li; Fang-qiong Li; Xiaoyi Wang; Yan-xue Xue & Lin Lu; Lin Lu
First AuthorLu-lu Yu
2009
Source PublicationPsychopharmacology
Correspondent Emailnzhwxy@heinfo.net ; linlu@bjmu.edu.cn
SubtypeArticle
Pages203–211
Abstract

Rationale Previous studies have shown that cannabinoid CB1 receptors play an important role in specific aspects of learning and memory, yet there has been no systematic study focusing on the involvement of cannabinoid CB1 receptors in methamphetamine-related reward memory.

Objectives The purpose of this study was to examine whether rimonabant, a cannabinoid CB1 receptor antagonist, would disrupt the consolidation and reconsolidation of methamphetamine-related reward memory, using conditioned place preference paradigm (CPP).

Materials and methods Separate groups of male Kunming mice were trained to acquire methamphetamine CPP. Vehicle or rimonabant (1 mg/kg or 3 mg/kg, i.p.) was given at different time points: immediately after each CPP training session (consolidation), 30 min before the reactivation of CPP (retrieval), or immediately after the reactivation of CPP (reconsolidation). Methamphetamine CPP was retested 24 h and 1 and 2 weeks after rimonabant administration.

KeywordCannabinoid CB1 receptor antagonist Conditioned place preference Methamphetamine Consolidation Reconsolidation
DOI10.1007/s00213-008-1450-y
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29145
Collection健康与遗传心理学研究室
Affiliation1.Insititute of Mental Health and Hebei Brain Ageing and Cognitive Neuroscience Laboratory, Hebei Medical University
2.National Institute on Drug Dependence, Peking University
Recommended Citation
GB/T 7714
Lu-lu Yu,Xue-yi Wang,Mei Zhao,et al. Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice[J]. Psychopharmacology,2009:203–211.
APA Lu-lu Yu.,Xue-yi Wang.,Mei Zhao.,Yu Liu.,Yan-qin Li.,...&Lin Lu.(2009).Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice.Psychopharmacology,203–211.
MLA Lu-lu Yu,et al."Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice".Psychopharmacology (2009):203–211.
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