PSYCH OpenIR  > 中国科学院心理健康重点实验室
Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia
Mei Hong Xiu; Dongmei Wang; Xiang Dong Du; Nan Chen; Shu Ping Tan; Yun Long Tan; Fu De Yang; Raymond Y Cho; Xiang Yang Zhang
2019
Source PublicationPsychoneuroendocrinology
Correspondent Emailwangdm@psych.ac.cn
SubtypeArticle
Pages10.1016/j.psyneuen.2019.06.006
Abstract

Multiple lines of evidence indicate that patients with chronic schizophrenia (SCZ) display executive dysfunction across the illness course. However, the potential molecular pathophysiologic mechanisms remain poorly elucidated. Neurodevelopmental changes caused by alterations of inflammatory mediators and neurotrophins have been shown to occur in the earliest stages of SCZ, and be associated with executive dysfunction (ED) in SCZ. Therefore, the current study was to investigate whether the interplay between BDNF and inflammatory mediators was involved in the disruption of executive function of long-term hospitalized patients with chronic SCZ. Serum cytokines and BDNF levels were measured in 164 long-term hospitalized patients with chronic SCZ and 42 healthy normal controls. Executive functions were assessed by verbal fluency tests (VFT), the Stroop word-color test (Stroop), and the Wisconsin card sorting tests (WCST).The results showed that the patients had higher IL-2, IL-6, IL-8, but lower TNF-α and BDNF compared to control subjects. In the patient group, BDNF was positively associated with IL-2 and IL-8 levels, while lower BDNF levels were correlated with ED measured by VFT and WCST tests. Multiple stepwise regression analyses confirmed that BDNF × IL-8 and BDNF × TNF-α were factors influencing the total score of VFT, while BDNF × IL-8 and BDNF × TNF-α were recognized as influencing factors for WCST scores. Our results suggest complex interactions between BDNF and cytokines were involved in the pathophysiology of executive function impairments in patients with SCZ.

DOI10.1016/j.psyneuen.2019.06.006
URL查看原文
Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29157
Collection中国科学院心理健康重点实验室
Affiliation1.Beijing HuiLongGuan Hospital, Peking University, Beijing, China
2.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
3.Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu Province, China
4.Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
Recommended Citation
GB/T 7714
Mei Hong Xiu,Dongmei Wang,Xiang Dong Du,et al. Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia[J]. Psychoneuroendocrinology,2019:10.1016/j.psyneuen.2019.06.006.
APA Mei Hong Xiu.,Dongmei Wang.,Xiang Dong Du.,Nan Chen.,Shu Ping Tan.,...&Xiang Yang Zhang.(2019).Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia.Psychoneuroendocrinology,10.1016/j.psyneuen.2019.06.006.
MLA Mei Hong Xiu,et al."Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia".Psychoneuroendocrinology (2019):10.1016/j.psyneuen.2019.06.006.
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