Institutional Repository of Key Laboratory of Mental Health, CAS
| Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia | |
| Xiu, Mei Hong1; Wang, Dong Mei2,3; Du, Xiang Dong4; Chen, Nan1; Tan, Shu Ping1; Tan, Yun Long1; Yang, Fu De1; Cho, Raymond Y.5; Zhang, Xiang Yang2,3 | |
| Corresponding Author | Wang, Dong Mei(wangdm@psych.ac.cn) |
| 2019-10-01 | |
| Source Publication | PSYCHONEUROENDOCRINOLOGY
 |
| ISSN | 0306-4530 |
| Volume | 108Pages:110-117 |
| Abstract | Multiple lines of evidence indicate that patients with chronic schizophrenia (SCZ) display executive dysfunction across the illness course. However, the potential molecular pathophysiologic mechanisms remain poorly elucidated. Neurodevelopmental changes caused by alterations of inflammatory mediators and neurotrophins have been shown to occur in the earliest stages of SCZ, and be associated with executive dysfunction (ED) in SCZ. Therefore, the current study was to investigate whether the interplay between BDNF and inflammatory mediators was involved in the disruption of executive function of long-term hospitalized patients with chronic SCZ. Serum cytokines and BDNF levels were measured in 112 long-term hospitalized patients with chronic SCZ and 44 healthy normal controls. Executive functions were assessed by verbal fluency tests (VFT), the Stroop word-color test (Stroop), and the Wisconsin card sorting tests (WCST).The results showed that the patients had higher IL-2, IL-6, IL-8, but lower TNF-alpha and BDNF compared to control subjects. In the patient group, BDNF was positively associated with IL-2 and IL-8 levels, while lower BDNF levels were correlated with ED measured by VFT and WCST tests. Multiple stepwise regression analyses confirmed that BDNF x IL-8 and BDNF x TNF-alpha were factors influencing the total score of VFT, while BDNF x IL-8 and BDNF x TNF-alpha were recognized as influencing factors for WCST scores. Our results suggest complex interactions between BDNF and cytokines were involved in the pathophysiology of executive function impairments in patients with SCZ. |
| Keyword | Schizophrenia BDNF Cytokine Interaction Executive function |
| DOI | 10.1016/j.psyneuen.2019.06.006 |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Organization | CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China |
| Funding Project | CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] |
| WOS Research Area | Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry |
| WOS Subject | Endocrinology & Metabolism ; Neurosciences ; Psychiatry |
| WOS ID | WOS:000484870800014 |
| Publisher | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS Keyword | NEUROTROPHIC FACTOR ; INFLAMMATORY CYTOKINES ; DRUG-NAIVE ; COGNITIVE PERFORMANCE ; GENE-EXPRESSION ; METAANALYSIS ; MARKERS ; SERUM ; DISORDER ; DEFICITS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/29157 |
| Collection | 中国科学院心理健康重点实验室 |
| Corresponding Author | Wang, Dong Mei |
| Affiliation | 1.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Jiangsu Provinc, Peoples R China 5.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA |
| Corresponding Author Affilication | Key Laboratory of Mental Health, CAS |
| Recommended Citation GB/T 7714 | Xiu, Mei Hong,Wang, Dong Mei,Du, Xiang Dong,et al. Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia[J]. PSYCHONEUROENDOCRINOLOGY,2019,108:110-117. |
| APA | Xiu, Mei Hong.,Wang, Dong Mei.,Du, Xiang Dong.,Chen, Nan.,Tan, Shu Ping.,...&Zhang, Xiang Yang.(2019).Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia.PSYCHONEUROENDOCRINOLOGY,108,110-117. |
| MLA | Xiu, Mei Hong,et al."Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia".PSYCHONEUROENDOCRINOLOGY 108(2019):110-117. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| XiuMH-SZ-BDNF-ILs051（258KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | View Application Full Text | |
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