PSYCH OpenIR  > 健康与遗传心理学研究室
Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory
Fang Shen; Yi-Jing Li; Xiao-Jing Shou; Cai-Lian Cui
First AuthorFang Shen
2012
Source PublicationNeurobiology of Learning and Memory
Correspondent Emailclcui@bjmu.edu.cn
ISSN1074-7427
SubtypeArticle
Volume98Issue:2Pages:130–138
QuartileQ1
Contribution Rank3
Abstract

Evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) signaling pathway plays a key role inmemory processing, but the actual participation of this signaling cascade in the hippocampal CA1 during morphine-induced reward memory remains unknown. In this study, we investigated the role of the NO/sGC/PKG signaling pathway in the CA1 on morphine-induced reward memory using a conditioned place preference (CPP) paradigm. We found that rats receiving an intraperitoneal (i.p.) injection of 4 mg/kg morphine exhibited CPP, whereas rats treated with only 0.2 mg/kg morphine failed to produce CPP. Intra-CA1 injection of the neuronal NO synthase (nNOS) inhibitor 7-NI, the sGC inhibitor ODQ or the PKG inhibitor Rp-8-Br-PET-cGMPS had no effect on the acquisition of CPP by 4 mg/kg morphine. Intra-CA1 injection of 7-NI blocked theconsolidation of CPP induced by 4 mg/kg morphine, and this amnesic effect of 7-NI was mimicked by ODQ and Rp-8-Br-PET-cGMPS. Intra-CA1 injection ofthe NOS substrate L-arg or the sGC activator YC-1 with an ineffective dose of morphine (0.2 mg/kg, i.p.) elicited CPP. This response induced by L-arg or YC-1 was reversed by pre-microinjection of Rp-8-Br-PET-cGMPS in the CA1. These results indicated that the activation of the NO/sGC/PKG signaling pathway inthe CA1 is necessary for the consolidation of morphine-related reward memory. (C) 2012 Elsevier Inc. All rights reserved.

KeywordNitric oxide signaling pathway Morphine Reward memory Hippocampal CA1 region
DOI10.1016/j.nlm.2012.07.005
URL查看原文
Indexed BySCI
Language英语
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29164
Collection健康与遗传心理学研究室
Affiliation1.Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100191, PR China
2.Key Laboratory of Neuroscience, The Ministry of Education and the Ministry of Health, 38 Xueyuan Road, Beijing 100191, PR China
3.Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100191, PR China
Recommended Citation
GB/T 7714
Fang Shen,Yi-Jing Li,Xiao-Jing Shou,et al. Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory[J]. Neurobiology of Learning and Memory,2012,98(2):130–138.
APA Fang Shen,Yi-Jing Li,Xiao-Jing Shou,&Cai-Lian Cui.(2012).Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory.Neurobiology of Learning and Memory,98(2),130–138.
MLA Fang Shen,et al."Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory".Neurobiology of Learning and Memory 98.2(2012):130–138.
Files in This Item:
File Name/Size DocType Version Access License
Role of the NO_sGC_P(878KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Fang Shen]'s Articles
[Yi-Jing Li]'s Articles
[Xiao-Jing Shou]'s Articles
Baidu academic
Similar articles in Baidu academic
[Fang Shen]'s Articles
[Yi-Jing Li]'s Articles
[Xiao-Jing Shou]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Fang Shen]'s Articles
[Yi-Jing Li]'s Articles
[Xiao-Jing Shou]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Role of the NO_sGC_PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.