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mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling
Chong Qi; Xinjuan Wang; Feifei Ge; Yijing Li; Fang Shen; Junkai Wang; Cailian Cui
First AuthorChong Qi ; Xinjuan Wang
2015
Source PublicationAddiction Biology
Correspondent Emailcui, c (clcui@bjmu.edu.cn)
ISSN1355-6215
SubtypeArticle
Volume20Issue:5Pages:927–940
QuartileQ1
Abstract

Emerging evidence indicates that metabotropic glutamate receptor 5 (mGluR5) critically modulates drug and drug-related behaviors. However, the role of mGluR5 in the opiate-induced contextual memory remains unclear. Here, we found that microinfusion of the mGluR5 antagonist 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP) into the nucleus accumbens (NAc) shell, but not into the core, significantly attenuated the expression of morphine conditioned place preference (CPP) in rats. Following the expression of morphine CPP, the protein level of membrane mGluR5 was selectively increased in the NAc shell. In primary striatal neurons, we observed that treatment with the mGluR5 agonist CHPG increased the phosphorylation level of extracellular signal-regulated kinase (ERK), which was dependent on the mGluR5-inositol-1,4,5-trisphosphate-reactive oxygen species (ROS) pathway. Moreover, the microinjection of the ROS scavenger Tempol into the NAc shell of rats blocked the expression of morphine CPP. Further, the administration of t-BOOH, a ROS donor, into the NAc shell rescued the retrieval impairment of morphine CPP produced by MTEP. Our previous study demonstrated that the expression of morphine CPP increased the phosphorylation of ERK selectively in the NAc shell. Thus, results of the present study suggest that mGluR5 in the NAc shell, but not in the core, is essential for the retrieval of morphine contextual memory, which is mediated at least in part, through the ROS/ERK signaling pathway. Uncovering the molecular basis of opiate contextual memory will benefit the development of new therapeutic approaches for the treatment of opiate addiction.

KeywordConditioned place preference (CPP) metabotropic glutamate receptor 5 (mGluR5) morphine nucleus accumbens (NAc) reactive oxygen species (ROS) retrieval
MOST Discipline Catalogue理学::生物学
DOI10.1111/adb.12222
Indexed BySCI
Language英语
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29166
Collection健康与遗传心理学研究室
Corresponding AuthorCailian Cui
Affiliation1.Peking Univ, Minist Educ, Key Lab Neurosci, Dept Neurobiol,Sch Basic Med Sci, Beijing
2.Peking Univ, Neurosci Res Inst, Natl Hlth & Family Planning Commiss, Beijing
Recommended Citation
GB/T 7714
Chong Qi,Xinjuan Wang,Feifei Ge,et al. mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling[J]. Addiction Biology,2015,20(5):927–940.
APA Chong Qi.,Xinjuan Wang.,Feifei Ge.,Yijing Li.,Fang Shen.,...&Cailian Cui.(2015).mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling.Addiction Biology,20(5),927–940.
MLA Chong Qi,et al."mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling".Addiction Biology 20.5(2015):927–940.
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