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Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population
Xiaohui Xiang1,2; Yin Jiang1; Yanjun Ni3; Min Fan3; Fang Shen1; Xuewei Wang1; Jisheng Han1; Cailian Cui1
First AuthorXiaohui Xiang
2012
Source PublicationPHYSIOLOGICAL GENOMICS
Correspondent Emailcailian cui (clcui@bjmu.edu.cn)
SubtypeArticle
Volume44Issue:5Pages:318–328
Abstract

Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population. PhysiolGenomics 44: 318–328, 2012. First published January 17, 2012; doi:10.1152/physiolgenomics.00162.2011.—Polymorphisms in the human catechol-O-methyltransferase (COMT) gene have been widely studied for their role in pain and analgesia. In this study, sensitivity to potassium iontophoresis, visual analog scale measurements for fixed twofold pain threshold stimulation and pain threshold changes induced by transcutaneous electrical acupoint stimulation (TEAS) were assessed in a population of healthy Chinese males. These results were correlated with the alleles of six single nucleotide polymorphisms (SNP) or diplotypes of common haplotypes designated as low pain sensitive, average pain sensitive, and high pain sensitive in the COMT gene of these subjects. Our results reveal that the alleles of each SNP are not significantly correlated with pain perception except for the rs4633 allele in the 2 Hz TEAS session (P _ 0.05). In addition, the six diplotypes of COMT haplotypes, which cover 92.5% of the Chinese population, are also not correlated with pain perception. Moreover, there were no significant differences in pain threshold changes induced by 2 and 100 Hz TEAS among the diplotypes of each SNP or the various haplotypes. These results suggest that COMT activity do not play a significant role in pain perception and TEAS-induced analgesia in the Chinese Han male population.

Keywordgene polymorphism haplotype analgesia electroacupuncture
DOI10.1152/physiolgenomics.00162.2011
Indexed BySCI
Language英语
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29170
Collection健康与遗传心理学研究室
Affiliation1.Neuroscience Research Institute, Peking University; Department of Neurobiology, School of Basic Medical Sciences, Peking University; Key Laboratory for Neuroscience of the Ministry of Education and the Ministry of Public Health, Beijing
2.Department of Physiology and Pathophysiology, Logistics University of Chinese People’s Armed Police Forces, Tianjin
3.Beijing People’s Armed Police Force, Beijing, China
Recommended Citation
GB/T 7714
Xiaohui Xiang,Yin Jiang,Yanjun Ni,et al. Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population[J]. PHYSIOLOGICAL GENOMICS,2012,44(5):318–328.
APA Xiaohui Xiang.,Yin Jiang.,Yanjun Ni.,Min Fan.,Fang Shen.,...&Cailian Cui.(2012).Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population.PHYSIOLOGICAL GENOMICS,44(5),318–328.
MLA Xiaohui Xiang,et al."Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population".PHYSIOLOGICAL GENOMICS 44.5(2012):318–328.
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