Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population | |
Xiaohui Xiang1,2; Yin Jiang1; Yanjun Ni3; Min Fan3; Fang Shen1; Xuewei Wang1; Jisheng Han1; Cailian Cui1 | |
第一作者 | Xiaohui Xiang |
通讯作者邮箱 | cailian cui (clcui@bjmu.edu.cn) |
摘要 | Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population. PhysiolGenomics 44: 318–328, 2012. First published January 17, 2012; doi:10.1152/physiolgenomics.00162.2011.—Polymorphisms in the human catechol-O-methyltransferase (COMT) gene have been widely studied for their role in pain and analgesia. In this study, sensitivity to potassium iontophoresis, visual analog scale measurements for fixed twofold pain threshold stimulation and pain threshold changes induced by transcutaneous electrical acupoint stimulation (TEAS) were assessed in a population of healthy Chinese males. These results were correlated with the alleles of six single nucleotide polymorphisms (SNP) or diplotypes of common haplotypes designated as low pain sensitive, average pain sensitive, and high pain sensitive in the COMT gene of these subjects. Our results reveal that the alleles of each SNP are not significantly correlated with pain perception except for the rs4633 allele in the 2 Hz TEAS session (P _ 0.05). In addition, the six diplotypes of COMT haplotypes, which cover 92.5% of the Chinese population, are also not correlated with pain perception. Moreover, there were no significant differences in pain threshold changes induced by 2 and 100 Hz TEAS among the diplotypes of each SNP or the various haplotypes. These results suggest that COMT activity do not play a significant role in pain perception and TEAS-induced analgesia in the Chinese Han male population. |
关键词 | gene polymorphism haplotype analgesia electroacupuncture |
2012 | |
语种 | 英语 |
DOI | 10.1152/physiolgenomics.00162.2011 |
发表期刊 | PHYSIOLOGICAL GENOMICS |
卷号 | 44期号:5页码:318–328 |
期刊论文类型 | Article |
收录类别 | SCI |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/29170 |
专题 | 健康与遗传心理学研究室 |
作者单位 | 1.Neuroscience Research Institute, Peking University; Department of Neurobiology, School of Basic Medical Sciences, Peking University; Key Laboratory for Neuroscience of the Ministry of Education and the Ministry of Public Health, Beijing 2.Department of Physiology and Pathophysiology, Logistics University of Chinese People’s Armed Police Forces, Tianjin 3.Beijing People’s Armed Police Force, Beijing, China |
推荐引用方式 GB/T 7714 | Xiaohui Xiang,Yin Jiang,Yanjun Ni,et al. Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population[J]. PHYSIOLOGICAL GENOMICS,2012,44(5):318–328. |
APA | Xiaohui Xiang.,Yin Jiang.,Yanjun Ni.,Min Fan.,Fang Shen.,...&Cailian Cui.(2012).Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population.PHYSIOLOGICAL GENOMICS,44(5),318–328. |
MLA | Xiaohui Xiang,et al."Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population".PHYSIOLOGICAL GENOMICS 44.5(2012):318–328. |
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