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Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers
Sun,Yu1; Wang,Xiaoni1; Wang,Yinshan2,3; Dong,Haoming2,3; Lu,Jie4; Scheininger,Tohar5; Ewers,Michael6; Jessen,Frank7; Zuo,Xi-Nian2,3; Han,Ying1,8,9,10
First AuthorSun,Yu

AbstractBackgroundSubjective cognitive decline (SCD) is characterized by self-reported cognitive deficits without measurable cognitive impairment. It has been suggested that individuals with SCD exhibited brain structural alterations in widespread cortical thinning or gray matter loss in the medial temporal and frontotemporal regions. Apolipoprotein E (APOE) ε4 allele is thought to be a genetic marker associated with risk of SCD. Neuropsychiatric symptoms may provide insight in detecting higher-risk elders for early Alzheimer’s disease as well. Therefore, we aim to explore the characteristics of brain morphology in SCD and to determine whether it is influenced by APOE ε4 as well as neuropsychiatric symptoms in SCD.MethodsA total of 138 cognitively normal older individuals from the SILCODE cohort underwent a clinical interview, neuropsychological assessments, a blood test, and MRI. A two-sample t-test was used to examine the cortex volume and bilateral cortical surface area alterations between SCD (n = 65) and controls (n = 73). A general linear model analysis was used to test for both main and interaction effects of clinical phenotype (SCD vs. controls) and APOE on global and regional cortex volume and bilateral cortical surface area and thickness. A multiple linear regression analysis was conducted to determine the effects of the APOE genotype on the relationships between morphometric features and neuropsychiatric symptoms in SCD.ResultsCompared with controls, individuals with SCD showed decreased total cortical volumes and cortical surface area. SCD APOE ε4 carriers showed additive reduction in the right cortical surface area. The evaluation scores of anxiety symptoms were negatively associated with the right cortical surface area in SCD APOE 4 non-carriers.ConclusionsIndividuals with SCD had an altered cortical surface area, and APOE genotype and anxiety symptoms are modified factors on the cortical surface area decrease in SCD.Trial (Identifier: NCT03370744). Registered 15 March 2017.

KeywordSubjective cognitive decline Apolipoprotein E Anxiety Cortical morphometry Alzheimer’s disease
Source PublicationAlzheimer's Research & Therapy
PublisherBioMed Central
WOS IDBMC:10.1186/s13195-019-0505-0
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Document Type期刊论文
Corresponding AuthorHan,Ying
Affiliation1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Inst Psychol, Res Ctr Lifespan Dev Mind & Brain CLIMB, Beijing, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
5.Child Mind Inst, Ctr Dev Brain, New York, NY USA
6.LMU, Inst Stroke & Dementia Res ISD, Munich, Germany
7.Univ Cologne, Fac Med, Dept Psychiat, Cologne, Germany
8.Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China
9.Beijing Inst Geriatr, Beijing, Peoples R China
10.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Sun,Yu,Wang,Xiaoni,Wang,Yinshan,et al. Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers[J]. Alzheimer's Research & Therapy,2019,11(1):1-10.
APA Sun,Yu.,Wang,Xiaoni.,Wang,Yinshan.,Dong,Haoming.,Lu,Jie.,...&Han,Ying.(2019).Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers.Alzheimer's Research & Therapy,11(1),1-10.
MLA Sun,Yu,et al."Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers".Alzheimer's Research & Therapy 11.1(2019):1-10.
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