PSYCH OpenIR  > 健康与遗传心理学研究室
Publication Place北京




Other Abstract

The present work includes two parts. The first part investigated age differences in emotion processing between Chinese younger and older adults. The second part investigated the neural activity and neuroanatomical substrates in late-life subclinical depression.

In the fist part, study I investigated age differences in emotion recognition between Chinese younger and older adults in a facial go/no-go task. Results showed that older adults were significantly slower than younger adults in sad face recognition, but there were no age differences in happy face recognition. In addition there was a negative correlation between the facial emotion recognition bias (RTsad-RThappy) and the negative emotional experience in older adults, suggesting that the age-related reduction in negative emotion experience might be due to the reduced negative face recognition in older adults. Study II investigated the resolution of emotional flanker interference in healthy older adults compared to their younger counterpart. The results revealed that older adults were not more susceptible to interference from incongruent Hanker arrows than younger adults, but were more vulnerable to disturbance from incongruent flanking emotion faces.

In the second part, study III investigated neural responses during emotion conflict processing in late-life subclinical depression in a functional magnetic resonance imaging (fMRI) study. Nineteen older adults with late-life subclinical depression and 18 matched controls were required to finish an emotion facial Stroop task. Preliminary imaging results showed that older adults with subclinical depression were more susceptible to interference from "sad" distracter relative to control individuals, the former showing elevated activity in the left supplementary motor area, inferior frontal gyrus, precentral gyrus, inferior occipital gyrus and cerebellum relative to control individuals during emotion conflict processing, while control individuals were more susceptible to interference from "happy" distracter relative to subjects with subclincal depressions, the former showing increased activity in bilateral inferior frontal gyrus, cerebellum and the left precentral gyrus, the right insular relative to subjects with sD during emotion conflict. Study IV explored the features of resting.state brain activity in latcdlifc subclinical depression.

Using three amygdale subdivisions: lateralbasal (LB), centromcdial (CM), and superficial (SF) as seed regions, functional connectivity was analyzed between amygdale subdivisions and other brain areas. The results showed that compared with controls, sD demonstrated increased functional connectivity between the right LB and the left fusiform, parahippocampal, middle temporal gyros and superior temporal gyros, between the left LB and the left superior temporal gyros, and between the right SF and the right superior temporal gyros, while sD demonstrated decreased functional connectivity between the left LB and the right inferior frontal gyros, middle frontal gyros, between the right LB and the left superior temporal gyros, and between the right SF and the right cerebellum, parahippocampal, Amygala, middle occipital gyros and superior parietal lobe. Study V explored whether individuals with sD showed abnormal diffuse microstructural of white matter using diffusion tensor imaging (DTI) technique. The DTI data in the present work is being processed.

Keyword情绪加工 老化效应 老年期亚临床抑郁 脑活动 脑结构
Document Type科技报告
Recommended Citation
GB/T 7714
马振玲. 情绪加工的老化效应以及老年期亚临床抑郁者的脑成像研究[R]. 北京,2011.
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