PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neurobiological mechanisms of TENS-induced analgesia
Peng, W. W.1; Tang, Z. Y.2,3; Zhang, F. R.4; Li, H.1; Kong, Y. Z.2,3; Iannetti, G. D.5,6; Hu, L.2,3,6,7
第一作者W.W. Peng
通讯作者邮箱l. hu(huli@psych.ac.cn)
心理所单位排序2
摘要

Pain inhibition by additional somatosensory input is the rationale for the widespread use of Transcutaneous Electrical Nerve Stimulation (TENS) to relieve pain. Two main types of TENS produce analgesia in animal models: high-frequency (similar to 50-100 Hz) and low-intensity 'conventional' TENS, and low-frequency (similar to 2-4 Hz) and high-intensity 'acupuncture-like' TENS. However, TENS efficacy in human participants is debated, raising the question of whether the analgesic mechanisms identified in animal models are valid in humans. Here, we used a sham-controlled experimental design to clarify the efficacy and the neurobiological effects of 'conventional' and 'acupuncture-like' TENS in 80 human volunteers. To test the analgesic effect of TENS we recorded the perceptual and brain responses elicited by radiant heat laser pulses that activate selectively A delta and C cutaneous nociceptors. To test whether TENS has a long-lasting effect on brain state we recorded spontaneous electrocortical oscillations. The analgesic effect of 'conventional' TENS was maximal when nociceptive stimuli were delivered homotopically, to the same hand that received the TENS. In contrast, 'acupuncture-like' TENS produced a spatially-diffuse analgesic effect, coupled with long-lasting changes both in the state of the primary sensorimotor cortex (S1/M1) and in the functional connectivity between S1/M1 and the medial prefrontal cortex, a core region in the descending pain inhibitory system. These results demonstrate that 'conventional' and 'acupuncture-like' TENS have different analgesic effects, which are mediated by different neurobiological mechanisms.

关键词Transcutaneous electrical nerve stimulation (TENS) Pain Analgesia Electroencephalography (EEG) Resting state Human
2019-07-15
语种英语
DOI10.1016/j.neuroimage.2019.03.077
发表期刊NEUROIMAGE
ISSN1053-8119
卷号195页码:396-408
期刊论文类型article
收录类别SCI
资助项目National Natural Science Foundation of China[31871127] ; National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025] ; Shenzhen Basic Research Project[JCYJ20170818093231953] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13506] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; Wellcome Trust (PAIN JLARAXR) ; European Research Council (PAINSTRAT)
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词ELECTRICAL NERVE-STIMULATION ; CORTICAL FUNCTIONAL CONNECTIVITY ; DIRECTED TRANSFER-FUNCTION ; HIGH-FREQUENCY ; INDUCED ANTIHYPERALGESIA ; INHIBITORY CONTROLS ; EXPERIMENTAL PAIN ; BRAIN POTENTIALS ; OPIOID RECEPTORS ; CAUSAL RELATIONS
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000468743000035
Q分类Q1
资助机构National Natural Science Foundation of China ; Shenzhen Basic Research Project ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences ; Wellcome Trust (PAIN JLARAXR) ; European Research Council (PAINSTRAT)
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/29257
专题中国科学院心理健康重点实验室
通讯作者Hu, L.
作者单位1.Shenzhen Univ, Coll Psychol & Sociol, Shenzhen, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Liaoning Normal Univ, Res Ctr Brain Cognit Neurosci, Dalian, Peoples R China
5.Ist Italiano Tecnol, Neurosci & Behav Lab, Rome, Italy
6.UCL, Dept Neurosci Physiol & Pharmacol, London, England
7.Guangzhou Med Univ, Affiliated Hosp 2, State Key Clin Specialty Pain Med, Dept Pain Management, Guangzhou, Guangdong, Peoples R China
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Peng, W. W.,Tang, Z. Y.,Zhang, F. R.,et al. Neurobiological mechanisms of TENS-induced analgesia[J]. NEUROIMAGE,2019,195:396-408.
APA Peng, W. W..,Tang, Z. Y..,Zhang, F. R..,Li, H..,Kong, Y. Z..,...&Hu, L..(2019).Neurobiological mechanisms of TENS-induced analgesia.NEUROIMAGE,195,396-408.
MLA Peng, W. W.,et al."Neurobiological mechanisms of TENS-induced analgesia".NEUROIMAGE 195(2019):396-408.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Neurobiological mech(4120KB)期刊论文出版稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Peng, W. W.]的文章
[Tang, Z. Y.]的文章
[Zhang, F. R.]的文章
百度学术
百度学术中相似的文章
[Peng, W. W.]的文章
[Tang, Z. Y.]的文章
[Zhang, F. R.]的文章
必应学术
必应学术中相似的文章
[Peng, W. W.]的文章
[Tang, Z. Y.]的文章
[Zhang, F. R.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。