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Interactive effects of corticotropin-releasing hormone receptor 1 gene and work stress on burnout in medical professionals in a Chinese Han population
He Shu-Chang1; Wu Shuang1; Du Xiang-Dong2; Jia Qiufang2; Wang Chao1; Wu Fengchun3; Ning Yuping3; Wang Dongmei4; Wang Li4; Zhang Xiang Yang3,4
First AuthorHe Shu-Chang
2019-06-01
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
Correspondent Emails.-c. he(shuchangh@pku.edu.cn ) ; x.y. zhang(zhangxy@psych.ac.cn)
ISSN0165-0327
Subtypearticle
Volume252Pages:1-8
Contribution Rank2
Abstract

Background: Burnout is a worked-related stress syndrome caused by long-term exposure to a stressful environment. Dysregulation of the hypothalamic- pituitary- adrenal (HPA) axis may be involved in both stress and burnout; an evaluation of genetic polymorphisms which alter activity in the HPA may be predictive of how likely an environment is to produce burnout. Methods: Using a cross-sectional design, this study examined whether corticotrophin-releasing hormone receptor 1 (CRHR1) gene polymorphism rs110402 is a risk factor for burnout; further, it explores whether the interaction of stress x CRHR1 gene predicts burnout in the healthcare workers in a Chinese Han population. House and Rizzo's work stress scale, Sources of Pressure Scale and Maslach Burnout Inventory-General Survey were administered to 712 participants from a large general hospital in Beijing. The CRHR1 rs110402 polymorphism was genotyped in 376 participants. Results: Our results showed significant positive inter-correlations between stressor, work stress and depressive scores (all p < 0.001) with only one exception. Males, younger age and higher educational level were associated with burnout (all p < 0.05). The presence of the CRHR1 rs110402 genotype was not correlated with the presence of job stress or burnout. However, we found statistically significant interaction between CRHR1 rs110402 and job stress on burnout (p < 0.05). Individuals homozygous for the A allele reported significantly higher emotional exhaustion than G allele carriers in the high stress group. Limitations: The sample was only chosen from the medical professions, and the sample size was relatively small. Only one polymorphism in CRHR1 gene was analyzed, while only about half of the total individuals were genotyped. Conclusions: Our results suggest a close relationship between work-related stress and burnout and that the A allele of the CRHR1 rs110402 polymorphism may enhance feelings of emotional exhaustion when experiencing work-related stress.

KeywordBurnout Stress Corticotrophin-releasing hormone receptor Genotype Interaction
DOI10.1016/j.jad.2019.03.084
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China
Funding ProjectNational Natural Science Foundation of China[81271491] ; National Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81371477]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000467801200001
PublisherELSEVIER SCIENCE BV
WOS KeywordDEPRESSIVE SYMPTOMS ; ADULT DEPRESSION ; JOB-SATISFACTION ; CORTISOL ; ASSOCIATION ; SUSCEPTIBILITY ; EXHAUSTION ; HEALTH ; CRHR1 ; RISK
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29263
Collection中国科学院心理健康重点实验室
Corresponding AuthorHe Shu-Chang; Zhang Xiang Yang
Affiliation1.School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing
2.Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Jiangsu, China
3.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
4.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Science, Beijing, China
Recommended Citation
GB/T 7714
He Shu-Chang,Wu Shuang,Du Xiang-Dong,et al. Interactive effects of corticotropin-releasing hormone receptor 1 gene and work stress on burnout in medical professionals in a Chinese Han population[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,252:1-8.
APA He Shu-Chang.,Wu Shuang.,Du Xiang-Dong.,Jia Qiufang.,Wang Chao.,...&Zhang Xiang Yang.(2019).Interactive effects of corticotropin-releasing hormone receptor 1 gene and work stress on burnout in medical professionals in a Chinese Han population.JOURNAL OF AFFECTIVE DISORDERS,252,1-8.
MLA He Shu-Chang,et al."Interactive effects of corticotropin-releasing hormone receptor 1 gene and work stress on burnout in medical professionals in a Chinese Han population".JOURNAL OF AFFECTIVE DISORDERS 252(2019):1-8.
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