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Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions
Wang, Yongxiang1; Du, Yifeng1; Li, Juan2,3; Qiu, Chengxuan1,4,5
First AuthorYongxiang Wang
2019-05-31
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
Correspondent Emailchengxuan qiu chengxuan.qiu@ki.se
ISSN1663-4365
Subtypearticle
Volume11Pages:11
Contribution Rank2
Abstract

Along with rapid global population aging, the age-related cognitive disorders such as mild cognitive impairment (MCI) and dementia have posed a serious threat to public health, health care system, and sustainable economic and societal development of all countries. In this narrative review, we seek to summarize the major epidemiological studies from the life-course perspective that investigate the influence of genetic susceptibility [e.g., apolipoprotein (APOE) epsilon 4 allele] and intellectual or psychosocial factors (e.g., educational attainments and leisure activities) as well as their interactions on cognitive phenotypes in aging. Numerous population-based studies have suggested that early-life educational attainments and socioeconomic status, midlife work complexity and social engagements, late-life leisure activities (social, physical, and mentally-stimulating activities), certain personality traits (e.g., high neuroticism and low conscientiousness), and depression significantly affect late-life cognitive phenotypes. Furthermore, certain intellectual or psychosocial factors (e. g., leisure activities and depression) may interact with genetic susceptibility (e.g., APOE epsilon 4 allele) to affect the phenotypes of cognitive aging such that risk or beneficial effects of these factors on cognitive function may vary by carrying the susceptibility genes. Current evidence from the randomized controlled trials that support the cognitive benefits of cognitive training among cognitive healthy older adults remains limited. The cognitive reserve hypothesis has been proposed to partly explain the beneficial effects of lifetime intellectual and psychosocial factors on late-life cognitive function. This implies that, from a life-course perspective, preventive intervention strategies targeting multiple modifiable intellectual and psychosocial factors could interfere with clinical expression of cognitive disorders in old age and delay the onset of dementia syndrome, and thus, may help achieve healthy brain aging.

Keywordpsychosocial factors genetic susceptibility interaction cognitive aging cognitive reserve life-course epidemiology
DOI10.3389/fnagi.2019.00129
Indexed BySCI
Language英语
Funding OrganizationNational R&D Program of the Ministry of Science and Technology of China ; National Nature Science Foundation of China ; Taishan Scholar Program of Shandong Province, China ; Swedish Council for Working Life and Social Research, Stockholm, Sweden ; Swedish Research Council (Vetenskapsradet), Stockholm, Sweden
Funding ProjectNational R&D Program of the Ministry of Science and Technology of China[2017YFC1310100] ; National Nature Science Foundation of China[31711530157] ; National Nature Science Foundation of China[8171101298] ; Taishan Scholar Program of Shandong Province, China ; Swedish Council for Working Life and Social Research, Stockholm, Sweden[2014-01382] ; Swedish Research Council (Vetenskapsradet), Stockholm, Sweden[2017-00740] ; Swedish Research Council (Vetenskapsradet), Stockholm, Sweden[2017-05819]
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000470163300001
PublisherFRONTIERS MEDIA SA
WOS KeywordGENOME-WIDE ASSOCIATION ; LATE-ONSET ALZHEIMER ; E EPSILON-4 STATUS ; PHYSICAL-ACTIVITY ; APOLIPOPROTEIN-E ; DEPRESSIVE SYMPTOMS ; INCIDENT DEMENTIA ; LEISURE ACTIVITIES ; OLDER-ADULTS ; OCCUPATIONAL COMPLEXITY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29347
Collection健康与遗传心理学研究室
Corresponding AuthorQiu, Chengxuan
Affiliation1.Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Stockholm Univ, Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Stockholm, Sweden
5.Stockholm Univ, Karolinska Inst, Ctr Alzheimers Res, Stockholm, Sweden
Recommended Citation
GB/T 7714
Wang, Yongxiang,Du, Yifeng,Li, Juan,et al. Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions[J]. FRONTIERS IN AGING NEUROSCIENCE,2019,11:11.
APA Wang, Yongxiang,Du, Yifeng,Li, Juan,&Qiu, Chengxuan.(2019).Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions.FRONTIERS IN AGING NEUROSCIENCE,11,11.
MLA Wang, Yongxiang,et al."Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions".FRONTIERS IN AGING NEUROSCIENCE 11(2019):11.
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