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Mesoscopic Neural Representations in Spatial Navigation
Kunz, Lukas1; Maidenbaum, Shachar2; Chen, Dong3; Wang, Liang3,4,5; Jacobs, Joshua2; Axmacher, Nikolai6
First AuthorKunz, Lukas
2019-07-01
Source PublicationTRENDS IN COGNITIVE SCIENCES
Correspondent Emaillukas.kunz@uniklinik-freiburg.de (l. kunz) ; shachar.maidenbaum@columbia.edu(s. maidenbaum) ; lwang@psych.ac.cn(l.wang) ; joshua.jacobs@columbia.edu(j. jacobs) ; nikolai.axmacher@rub.de (n. axmacher)
ISSN1364-6613
Subtypearticle
Volume23Issue:7Pages:615-630
Contribution Rank3
Abstract

Recent evidence suggests that mesoscopic neural oscillations measured via intracranial electroencephalography exhibit spatial representations, which were previously only observed at the micro- and macroscopic level of brain organization. Specifically, theta (and gamma) oscillations correlate with movement, speed, distance, specific locations, and goal proximity to boundaries. In entorhinal cortex (EC), they exhibit hexadirectional modulation, which is putatively linked to grid cell activity. Understanding this mesoscopic neural code is crucial because information represented by oscillatory power and phase may complement the information content at other levels of brain organization. Mesoscopic neural oscillations help bridge the gap between single-neuron and macroscopic brain signals of spatial navigation and may provide a mechanistic basis for novel biomarkers and therapeutic targets to treat diseases causing spatial disorientation.

DOI10.1016/j.tics.2019.04.011
Indexed BySCI
Language英语
Funding OrganizationFederal Ministry of Education and Research (BMBF) ; National Science Foundation (NSF) ; National Institutes of Health (NIH) ; NIH ; NSF ; Strategic Priority Research Program of Chinese Academy of Science ; Beijing Municipal Science and Technology Commission ; CAS Interdisciplinary Innovation Team ; Natural Science Foundation of China ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Funding ProjectFederal Ministry of Education and Research (BMBF)[01GQ1705A] ; National Science Foundation (NSF)[BCS-1724243] ; National Institutes of Health (NIH)[563386] ; NIH[MH061975] ; NIH[MH104606] ; NSF[BCS-1724243] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32010300] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] ; Natural Science Foundation of China[81422024] ; Natural Science Foundation of China[31771255] ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[316803389 - SFB 1280] ; [122679504 - SFB 874]
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS SubjectBehavioral Sciences ; Neurosciences ; Psychology, Experimental
WOS IDWOS:000472025200011
PublisherELSEVIER SCIENCE LONDON
WOS KeywordLOCAL-FIELD POTENTIALS ; HIPPOCAMPAL THETA ACTIVITY ; PLACE-CELL SEQUENCES ; VISUAL SPACE ; BOLD SIGNAL ; GRID CELLS ; ENVIRONMENTAL BOUNDARIES ; 3-DIMENSIONAL SPACE ; BRAIN OSCILLATIONS ; INTRACRANIAL EEG
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29404
Collection中国科学院心理健康重点实验室
Corresponding AuthorKunz, Lukas; Maidenbaum, Shachar; Wang, Liang; Axmacher, Nikolai
Affiliation1.Univ Freiburg, Fac Med, Med Ctr, Epilepsy Ctr, Freiburg, Germany
2.Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA
3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Ruhr Univ Bochum, Inst Cognit Neurosci, Fac Psychol, Dept Neuropsychol, Bochum, Germany
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Kunz, Lukas,Maidenbaum, Shachar,Chen, Dong,et al. Mesoscopic Neural Representations in Spatial Navigation[J]. TRENDS IN COGNITIVE SCIENCES,2019,23(7):615-630.
APA Kunz, Lukas,Maidenbaum, Shachar,Chen, Dong,Wang, Liang,Jacobs, Joshua,&Axmacher, Nikolai.(2019).Mesoscopic Neural Representations in Spatial Navigation.TRENDS IN COGNITIVE SCIENCES,23(7),615-630.
MLA Kunz, Lukas,et al."Mesoscopic Neural Representations in Spatial Navigation".TRENDS IN COGNITIVE SCIENCES 23.7(2019):615-630.
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