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Altered Static and Temporal Dynamic Amplitude of Low-Frequency Fluctuations in the Background Network During Working Memory States in Mild Cognitive Impairment
Wang, Pengyun1; Li, Rui1; Liu, Bei2; Wang, Cheng3; Huang, Zirui4,5; Dai, Rui6; Song, Bogeng7; Yuan, Xiao8; Yu, Jing9; Li, Juan1
First AuthorWang, Pengyun
2019-06-28
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
Correspondent Emailjing yu helen12@swu.edu.cn ; juan li lijuan@psych.ac.cn
ISSN1663-4365
Subtypearticle
Volume11Pages:10
Contribution Rank1
Abstract

Previous studies investigating working memory performance in patients with mild cognitive impairment (MCI) have mainly focused on the neural mechanisms of alterations in activation. To date, very few studies have investigated background network alterations in the working memory state. Therefore, the present study investigated the static and temporal dynamic changes in the background network in MCI patients during a working memory task. A hybrid delayed-match-to-sample task was used to examine working memory performance in MCI patients. Functional magnetic resonance imaging (fMRI) data were collected and the marker of amplitude of low-frequency fluctuations (ALFF) was used to investigate alterations in the background network. The present study demonstrated static and dynamic alterations of ALFF in MCI patients during working memory tasks, relative to the resting state. Traditional static analysis revealed that ALFF decreased in the right ventrolateral prefrontal cortex (VLPFC), right dorsolateral PFC (DLPFC), and left supplementary motor area for normal controls (NCs) in the working memory state. However, the same regions showed increased ALFF in MCI patients. Furthermore, relative to NCs, MCI patients demonstrated altered performance-related functional connectivity (FC) patterns, with the right VLPFC and right DLPFC as ROIs. In terms of temporal dynamic analysis, the present study found that in the working memory state dynamic ALFF of bilateral thalamus regions was increased in NCs but decreased in MCI patients. Additionally, MCI patients demonstrated altered performance-related coefficient of variation patterns; the regions in MCI patients were larger and more widely distributed in the parietal and temporal lobes, relative to NCs. This is the first study to examine static and temporal dynamic alterations of ALFF in the background network of MCI patients in working memory states. The results extend previous studies by providing a new perspective on the neural mechanisms of working memory deficits in MCI patients.

Keywordmild cognitive impairment working memory amplitude of low-frequency fluctuations background network temporal dynamics
DOI10.3389/fnagi.2019.00152
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China ; Beijing Municipal Science & Technology Commission ; International cooperation project of the Chinese Academy of Sciences ; National Natural Science Foundation of China
Funding ProjectNational Key Research and Development Program of China[2017YFB1401203] ; National Key Research and Development Program of China[2018YFC2000303] ; National Key Research and Development Program of China[2018YFC2001701] ; National Key Research and Development Program of China[2016YFC1305900] ; Beijing Municipal Science & Technology Commission[Z171100000117006] ; Beijing Municipal Science & Technology Commission[Z171100008217006] ; International cooperation project of the Chinese Academy of Sciences[153111KYSB20180024] ; National Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[31470998] ; National Natural Science Foundation of China[31861133011] ; National Natural Science Foundation of China[31400895] ; National Natural Science Foundation of China[31871123]
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000473279300001
PublisherFRONTIERS MEDIA SA
WOS KeywordFUNCTIONAL CONNECTIVITY ; AMNESTIC MCI ; ATTENTION ; FMRI ; REPRESENTATION ; INFORMATION ; HOMOGENEITY ; DEMENTIA ; TRACKING ; OBJECTS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29414
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Jing; Li, Juan
Affiliation1.Chinese Acad Sci, Ctr Aging Psychol, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Inst Disaster Prevent, Dept Human Resources, Beijing, Peoples R China
3.Zhejiang Normal Univ, Dept Psychol, Jinhua, Zhejiang, Peoples R China
4.Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA
5.Univ Michigan, Ctr Consciousness Sci, Ann Arbor, MI 48109 USA
6.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
7.Capital Normal Univ, Sch Psychol, Beijing, Peoples R China
8.China Univ Polit Sci & Law, Sch Sociol, Beijing, Peoples R China
9.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Pengyun,Li, Rui,Liu, Bei,et al. Altered Static and Temporal Dynamic Amplitude of Low-Frequency Fluctuations in the Background Network During Working Memory States in Mild Cognitive Impairment[J]. FRONTIERS IN AGING NEUROSCIENCE,2019,11:10.
APA Wang, Pengyun.,Li, Rui.,Liu, Bei.,Wang, Cheng.,Huang, Zirui.,...&Li, Juan.(2019).Altered Static and Temporal Dynamic Amplitude of Low-Frequency Fluctuations in the Background Network During Working Memory States in Mild Cognitive Impairment.FRONTIERS IN AGING NEUROSCIENCE,11,10.
MLA Wang, Pengyun,et al."Altered Static and Temporal Dynamic Amplitude of Low-Frequency Fluctuations in the Background Network During Working Memory States in Mild Cognitive Impairment".FRONTIERS IN AGING NEUROSCIENCE 11(2019):10.
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