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Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis
Kong, Li1,2; Cui, Huiru3; Zhang, Tianhong3; Wang, Ya2; Huang, Jia2; Zhu, Yikang3; Tang, Yingying3; Herold, Christina J.4; Schroeder, Johannes4; Cheung, Eric F. C.5; Chan, Raymond C. K.2,6; Wang, Jijun3,7
第一作者Li Kong
通讯作者邮箱jijunwang27@163.com
心理所单位排序2
摘要

Neurological soft signs (NSSs), conventionally defined as subtle neurological abnormalities, are frequently found in individuals with schizophrenia. Many neuroimaging studies have also reported that NSSs are associated with grey matter changes in patients with schizophrenia at different stages of the illness. However, these findings may be confounded by the effect of antipsychotic medications, chronicity, and duration of untreated psychosis. Examining NSSs in individuals with ultra-high risk (UHR) for psychosis may help to identify the neuroanatomical substrates of NSSs related to the illness itself and to avoid these potential confounding effects. A sample of 21 individuals with UHR were included in the present study. NSSs were rated using the abridged version of the Cambridge Neurological Inventory. Grey matter volume was assessed using optimized voxel-based morphometry on images acquired by a high-resolution 3-T magnetic resonance imaging scanner. We found that higher NSS scores in individuals with UHR were associated with decreased grey matter volume at the superior and medial frontal cortex, the rectal cortex, the pre- and post-central cortex, the insula, the caudate, and the cerebellum. Our results suggest that these brain structural characteristics may represent the neuroanatomical substrate of NSSs in individuals with UHR. These findings contribute to the understanding of the intrinsic features of psychosis associated with NSSs and may provide insights into pre-schizophrenia pathophysiology.

关键词grey matter volume magnetic resonance imaging neurological soft signs ultra-high risk for psychosis voxel-based morphometry
2019-06-01
语种英语
DOI10.1002/pchj.258
发表期刊PSYCH JOURNAL
ISSN2046-0252
卷号8期号:2页码:252-260
期刊论文类型article
收录类别SCI
资助项目Ministry of Science and Technology of China[2016YFC1306803] ; Science Foundation of Shanghai Mental Health Centre[SMHCRSD01] ; National Basic Research Program of China (Precision Psychiatry Program)[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; National Natural Science Foundation of China[81601170] ; Shanghai Mental Health Center Foundation[2016-YJ-03] ; Shanghai Municipal Commission of Health and Family Planning Foundation[20164Y0215]
出版者WILEY
WOS关键词BASAL GANGLIA ; SCHIZOPHRENIA ; BRAIN ; CORTEX ; MORPHOLOGY ; VOLUME ; DYSFUNCTION ; VALIDITY
WOS研究方向Psychology
WOS类目Psychology, Multidisciplinary
WOS记录号WOS:000472121200008
资助机构Ministry of Science and Technology of China ; Science Foundation of Shanghai Mental Health Centre ; National Basic Research Program of China (Precision Psychiatry Program) ; Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for the Leading Talents in S T ; National Natural Science Foundation of China ; Shanghai Mental Health Center Foundation ; Shanghai Municipal Commission of Health and Family Planning Foundation
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/29441
专题中国科学院心理健康重点实验室
通讯作者Wang, Jijun
作者单位1.Shanghai Normal Univ, Coll Educ, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China
4.Heidelberg Univ, Dept Psychiat, Sect Geriatr Psychiat, Heidelberg, Germany
5.Castle Peak Hosp, Dept Adult Psychiat, Hong Kong, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
第一作者单位认知与发展心理学研究室
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GB/T 7714
Kong, Li,Cui, Huiru,Zhang, Tianhong,et al. Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis[J]. PSYCH JOURNAL,2019,8(2):252-260.
APA Kong, Li.,Cui, Huiru.,Zhang, Tianhong.,Wang, Ya.,Huang, Jia.,...&Wang, Jijun.(2019).Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis.PSYCH JOURNAL,8(2),252-260.
MLA Kong, Li,et al."Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis".PSYCH JOURNAL 8.2(2019):252-260.
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