PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis
Kong, Li1,2; Cui, Huiru3; Zhang, Tianhong3; Wang, Ya2; Huang, Jia2; Zhu, Yikang3; Tang, Yingying3; Herold, Christina J.4; Schroeder, Johannes4; Cheung, Eric F. C.5; Chan, Raymond C. K.2,6; Wang, Jijun3,7
First AuthorLi Kong
Contribution Rank2

Neurological soft signs (NSSs), conventionally defined as subtle neurological abnormalities, are frequently found in individuals with schizophrenia. Many neuroimaging studies have also reported that NSSs are associated with grey matter changes in patients with schizophrenia at different stages of the illness. However, these findings may be confounded by the effect of antipsychotic medications, chronicity, and duration of untreated psychosis. Examining NSSs in individuals with ultra-high risk (UHR) for psychosis may help to identify the neuroanatomical substrates of NSSs related to the illness itself and to avoid these potential confounding effects. A sample of 21 individuals with UHR were included in the present study. NSSs were rated using the abridged version of the Cambridge Neurological Inventory. Grey matter volume was assessed using optimized voxel-based morphometry on images acquired by a high-resolution 3-T magnetic resonance imaging scanner. We found that higher NSS scores in individuals with UHR were associated with decreased grey matter volume at the superior and medial frontal cortex, the rectal cortex, the pre- and post-central cortex, the insula, the caudate, and the cerebellum. Our results suggest that these brain structural characteristics may represent the neuroanatomical substrate of NSSs in individuals with UHR. These findings contribute to the understanding of the intrinsic features of psychosis associated with NSSs and may provide insights into pre-schizophrenia pathophysiology.

Keywordgrey matter volume magnetic resonance imaging neurological soft signs ultra-high risk for psychosis voxel-based morphometry
Source PublicationPSYCH JOURNAL
Indexed BySCI
Funding ProjectMinistry of Science and Technology of China[2016YFC1306803] ; Science Foundation of Shanghai Mental Health Centre[SMHCRSD01] ; National Basic Research Program of China (Precision Psychiatry Program)[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; National Natural Science Foundation of China[81601170] ; Shanghai Mental Health Center Foundation[2016-YJ-03] ; Shanghai Municipal Commission of Health and Family Planning Foundation[20164Y0215]
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000472121200008
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWang, Jijun
Affiliation1.Shanghai Normal Univ, Coll Educ, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China
4.Heidelberg Univ, Dept Psychiat, Sect Geriatr Psychiat, Heidelberg, Germany
5.Castle Peak Hosp, Dept Adult Psychiat, Hong Kong, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
First Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Kong, Li,Cui, Huiru,Zhang, Tianhong,et al. Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis[J]. PSYCH JOURNAL,2019,8(2):252-260.
APA Kong, Li.,Cui, Huiru.,Zhang, Tianhong.,Wang, Ya.,Huang, Jia.,...&Wang, Jijun.(2019).Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis.PSYCH JOURNAL,8(2),252-260.
MLA Kong, Li,et al."Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis".PSYCH JOURNAL 8.2(2019):252-260.
Files in This Item:
File Name/Size DocType Version Access License
Neurological soft si(2898KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Kong, Li]'s Articles
[Cui, Huiru]'s Articles
[Zhang, Tianhong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Kong, Li]'s Articles
[Cui, Huiru]'s Articles
[Zhang, Tianhong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Kong, Li]'s Articles
[Cui, Huiru]'s Articles
[Zhang, Tianhong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.