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Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes
Zhen, Yan-Feng1; Liu, Xing-Yu2; Li, Yu-Kai1; Fang, Hui1; Cassidy, Ryan M.3; Zhang, Xiang Yang4
Corresponding AuthorFang, Hui(jane791115@126.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
2019-07-01
Source PublicationPSYCHOSOMATIC MEDICINE
ISSN0033-3174
Volume81Issue:6Pages:488-494
AbstractObjective Although a reduction in brain-derived neurotrophic factor (BDNF) has been implicated as a cause of cognitive impairment in type 2 diabetes mellitus (T2DM), the role of sex in moderating this effect has not been explored. Methods We compared the difference in serum BDNF and performance on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) between 96 men and 134 women with T2DM. We compared this with the difference in serum BDNF and performance in the control group (104 men, 144 women). Results Patients with T2DM performed worse on most RBANS indices (eta(2) = 0.372, all p < .05); within T2DM patients, men performed worse than women on the delayed memory score (74.1 (12.1) versus 79.9 (11.5), p = .002) and on the total score (71.4 (11.5) versus 76.5 (10.8), p = .025). Serum BDNF was lower in patients with T2DM versus controls (7.5 (2.7) ng/ml versus 11.5 (2.7) ng/ml, p < .001), and in men compared with women (6.9 (2.4) versus 7.9 (2.8), p = .024). Serum BDNF levels positively correlated with delayed memory score in patients with T2DM (beta = 0.19, p = .007). However, this association was only observed in women, not in men (p(interaction) = 0.04). Among healthy controls, no sex differences were noted in either RBANS or BDNF levels (eta(2) = 0.04, Cohen's d < 0.163, all p > .05). Conclusions Our results show sex differences in poorer cognitive performance, lower BDNF concentration, and their relationship in T2DM patients, suggesting that female sex may be a protective factor for cognitive decline in T2DM patients. However, the findings should be regarded as preliminary because of the cross-sectional design and chronicity of the diabetes.
Keywordassociation BDNF cognition serum sex difference
DOI10.1097/PSY.0000000000000709
Indexed BySCI ; SCI
Language英语
Funding OrganizationNational Natural Science Foundation of China
Funding ProjectNational Natural Science Foundation of China[81371477]
WOS Research AreaPsychiatry ; Psychology
WOS SubjectPsychiatry ; Psychology ; Psychology, Multidisciplinary
WOS IDWOS:000475406800001
PublisherLIPPINCOTT WILLIAMS & WILKINS
WOS KeywordMIDDLE-AGED MEN ; SYNAPTIC-TRANSMISSION ; CIGARETTE-SMOKING ; HUMAN-MEMORY ; BDNF LEVELS ; DECLINE ; GENDER ; RISK ; COMPLICATIONS ; MODULATION
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29518
Collection中国科学院心理健康重点实验室
Corresponding AuthorFang, Hui; Zhang, Xiang Yang
Affiliation1.Tangshan Gongren Hosp, Dept Endocrinol, 27 Wenhua Rd, Tangshan, Hebei, Peoples R China
2.Tangshan Gongren Hosp, Dept Neurosurg, Tangshan, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Zhen, Yan-Feng,Liu, Xing-Yu,Li, Yu-Kai,et al. Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes[J]. PSYCHOSOMATIC MEDICINE,2019,81(6):488-494.
APA Zhen, Yan-Feng,Liu, Xing-Yu,Li, Yu-Kai,Fang, Hui,Cassidy, Ryan M.,&Zhang, Xiang Yang.(2019).Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes.PSYCHOSOMATIC MEDICINE,81(6),488-494.
MLA Zhen, Yan-Feng,et al."Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes".PSYCHOSOMATIC MEDICINE 81.6(2019):488-494.
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