PSYCH OpenIR  > 健康与遗传心理学研究室
脑动态功模式稳定性研究
李乐
2019-06
Publication Place北京
Contribution Rank1
Abstract

大脑以分布式的神经连接对信息形成稳定的表征,是其有效运转的关键。虽然大脑的功能组织模式是动态变化的,但仍呈现出一定程度的稳定性,即脑功能活动或连接模式在一个连续状态内的多个时刻之间表现出相似性。虽然己有许多对脑动态性特征的研究,然而目前对脑功能稳定性的研究非常有限,对于大脑各网络的稳定性分布模式仍不清楚。本研究拟通过测量全脑动态功能连接(dynamic functional connectivity)的前后一致性,描绘出大脑体素水平的功能稳定性。我们首先采用一组从公开数据库获取的、具有重复测量的静息态(resting state)功能磁共振成像(fMRI)数据,比较了不同脑区、特别是高级联合脑区(high-order association region)和单模态脑区(unimodal region)的功能稳定性差异,并检验脑功能稳定性指标的可靠性。研究结果显示,在静息态下高级联合脑区呈现高稳定性,尤其是位于默认网络的脑区,而初级感觉运动脑区则呈现相对较低稳定性。功能稳定性在不同脑区和脑网络之间的差异在同一组被试前后两次测量间是一致的,反应了这一指标良好的重测信度。在建立了脑功能稳定性的具体测量方法之后,我们进一步从公开数据库获取两组仃叨RI数据,一组作为发现组,另一组作为验证组,这两组数据采集了儿童和青少年在观看电影时和静息态的脑活动图像。我们通过观影状态和静息态的比较,考察脑功能稳定性如何受到自然情境任务的调节,并重点关注视觉联合皮层与视觉初级皮层的差异。对发现组的分析结果显示,相比于静息态,初级视觉皮层的功能稳定性在观看电影时降低了;相反,视觉加工通路的高级联合脑区的功能稳定性在观看电影时升高了。验证组的分析也发现了观影状态和静息态之间类似的功能稳定性差异,说明了这一结果具有良好的可重复性。本研究对脑功能稳定性分布模式和受自然情境任务调节模式的研究发现,从动态网络角度为大脑的稳定性特征提供了证据支持,并有望为发展心理状态检查和疾病诊断的神经标志物提供参考。

Other Abstract

Stable representation of information in distributed neural connectivity is critical to function effectively in the world. Despite the dynamic nature of the brain's functional architecture, characterizing its temporal stability has been largely neglected. Here we characterized stability of functional architecture for each brain voxel by measuring the concordance of dynamic functional connectivity (DFC) over time, and explored how stability was modified by movie watching. High-order association regions, especially the default mode network, demonstrated high stability during resting state scans, while primary sensory-motor cortices revealed relatively lower stability. During movie watching, stability in the primary visual cortex was decreased, which was associated with larger DFC variation with neighboring regions. By contrast, higher-order regions in the ventral and dorsal visual stream demonstrated increased stability. The distribution of functional stability and its modification describes a profile of the brain's stability property, which may be useful reference for examining distinct mental states and disorders.

Keyword脑功能稳定性 高级联合脑区 静息态 观看电影 动态功能连接
Pages46
Language中文
Document Type科技报告
Identifierhttp://ir.psych.ac.cn/handle/311026/29539
Collection健康与遗传心理学研究室
Affiliation中国科学院心理研究所
Recommended Citation
GB/T 7714
李乐. 脑动态功模式稳定性研究[R]. 北京,2019.
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