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Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation | |
Kunz, Lukas1; Wang, Liang2,3,4; Lachner-Piza, Daniel1; Zhang, Hui5; Brandt, Armin1; Dumpelmann, Matthias1; Reinacher, Peter C.6; Coenen, Volker A.6; Chen, Dong7; Wang, Wen-Xu7; Zhou, Wenjing8; Liang, Shuli9; Grewe, Philip10; Bien, Christian G.10; Bierbrauer, Anne5; Schroder, Tobias Navarro11; Schulze-Bonhage, Andreas1; Axmacher, Nikolai5 | |
第一作者 | Kunz, Lukas |
通讯作者邮箱 | lukas.kunz@uniklinik-freiburg.de (l.k.) ; nikolai.axmacher@rub.de (n.a.) |
心理所单位排序 | 2 |
摘要 | Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coupled reactivation, but evidence for similar mechanisms during complex behaviors such as goal-directed navigation is scarce. We examined intracranial electroencephalography recordings of epilepsy patients performing an object-location memory task in a virtual environment. We report that large-scale electrophysiological representations of objects that cue for specific goal locations are dynamically reactivated during goal-directed navigation. Reactivation of different cue representations occurred at stimulus-specific hippocampal theta phases. Locking to more distinct theta phases predicted better memory performance, identifying hippocampal theta phase coding as a mechanism for separating competing goals. Our findings suggest shared neural mechanisms between working memory and goal-directed navigation and provide new insights into the functions of the hippocampal theta rhythm. |
2019-07-01 | |
DOI | 10.1126/sciadv.aav8192 |
发表期刊 | SCIENCE ADVANCES |
ISSN | 2375-2548 |
卷号 | 5期号:7页码:17 |
收录类别 | SCI ; EI |
资助项目 | BMBF[01GQ1705A] ; NSF[BCS-1724243] ; NIH[563386] ; BrainLinks-Brain Tools Cluster of Excellence - German Research Foundation (DFG)[EXC 1086] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32010300] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] ; Natural Science Foundation of China[81422024] ; Natural Science Foundation of China[31771255] ; Else Kroner-Fresenius-Stiftung (Bad Homburg, Germany) ; German Ministry for Economic Affairs and Energy (Berlin, Germany) ; Medical Faculty of the University of Freiburg (Freiburg, Germany) ; von Bodelschwingh Foundation Bethel, Bielefeld, Germany ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[316803389 -SFB 1280] ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[122679504 -SFB 874] |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
WOS关键词 | NEURAL REPRESENTATIONS ; OSCILLATIONS ; MEMORY ; MECHANISMS ; DISTANCE ; CORTEX ; REWARD |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000478770400035 |
WOS分区 | Q1 |
资助机构 | BMBF ; NSF ; NIH ; BrainLinks-Brain Tools Cluster of Excellence - German Research Foundation (DFG) ; Strategic Priority Research Program of Chinese Academy of Science ; Beijing Municipal Science and Technology Commission ; CAS Interdisciplinary Innovation Team ; Natural Science Foundation of China ; Else Kroner-Fresenius-Stiftung (Bad Homburg, Germany) ; German Ministry for Economic Affairs and Energy (Berlin, Germany) ; Medical Faculty of the University of Freiburg (Freiburg, Germany) ; von Bodelschwingh Foundation Bethel, Bielefeld, Germany ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/29566 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Kunz, Lukas; Axmacher, Nikolai |
作者单位 | 1.Univ Freiburg, Fac Med, Med Ctr, Epilepsy Ctr, Freiburg, Germany 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Ruhr Univ Bochum, Fac Psychol, Dept Neuropsychol, Inst Cognit Neurosci, Bochum, Germany 6.Univ Med Ctr, Stereotact & Funct Neurosurg, Freiburg, Germany 7.Beijing Normal Univ, Sch Syst Sci, Beijing, Peoples R China 8.Tsinghua Univ, Yuquan Hosp, Dept Epilepsy Ctr, Beijing, Peoples R China 9.PLA, Affiliated Hosp 1, Dept Neurosurg, Gen Hosp, Beijing, Peoples R China 10.Krankenhaus Mara, Bethel Epilepsy Ctr, Bielefeld, Germany 11.Norwegian Univ Sci & Technol, Kavli Inst Syst Neurosci, Ctr Neural Computat,NTNU, Egil & Pauline Braathen & Fred Kavli Ctr Cort Mic, Trondheim, Norway |
推荐引用方式 GB/T 7714 | Kunz, Lukas,Wang, Liang,Lachner-Piza, Daniel,et al. Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation[J]. SCIENCE ADVANCES,2019,5(7):17. |
APA | Kunz, Lukas.,Wang, Liang.,Lachner-Piza, Daniel.,Zhang, Hui.,Brandt, Armin.,...&Axmacher, Nikolai.(2019).Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation.SCIENCE ADVANCES,5(7),17. |
MLA | Kunz, Lukas,et al."Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation".SCIENCE ADVANCES 5.7(2019):17. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Hippocampal theta ph(6947KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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