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Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation
Kunz, Lukas1; Wang, Liang2,3,4; Lachner-Piza, Daniel1; Zhang, Hui5; Brandt, Armin1; Dumpelmann, Matthias1; Reinacher, Peter C.6; Coenen, Volker A.6; Chen, Dong7; Wang, Wen-Xu7; Zhou, Wenjing8; Liang, Shuli9; Grewe, Philip10; Bien, Christian G.10; Bierbrauer, Anne5; Schroder, Tobias Navarro11; Schulze-Bonhage, Andreas1; Axmacher, Nikolai5
First AuthorKunz, Lukas
2019-07-01
Source PublicationSCIENCE ADVANCES
Correspondent Emaillukas.kunz@uniklinik-freiburg.de (l.k.) ; nikolai.axmacher@rub.de (n.a.)
ISSN2375-2548
Subtypearticle
Volume5Issue:7Pages:17
Contribution Rank2
Abstract

Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coupled reactivation, but evidence for similar mechanisms during complex behaviors such as goal-directed navigation is scarce. We examined intracranial electroencephalography recordings of epilepsy patients performing an object-location memory task in a virtual environment. We report that large-scale electrophysiological representations of objects that cue for specific goal locations are dynamically reactivated during goal-directed navigation. Reactivation of different cue representations occurred at stimulus-specific hippocampal theta phases. Locking to more distinct theta phases predicted better memory performance, identifying hippocampal theta phase coding as a mechanism for separating competing goals. Our findings suggest shared neural mechanisms between working memory and goal-directed navigation and provide new insights into the functions of the hippocampal theta rhythm.

DOI10.1126/sciadv.aav8192
Indexed BySCI
Language英语
Funding OrganizationBMBF ; NSF ; NIH ; BrainLinks-Brain Tools Cluster of Excellence - German Research Foundation (DFG) ; Strategic Priority Research Program of Chinese Academy of Science ; Beijing Municipal Science and Technology Commission ; CAS Interdisciplinary Innovation Team ; Natural Science Foundation of China ; Else Kroner-Fresenius-Stiftung (Bad Homburg, Germany) ; German Ministry for Economic Affairs and Energy (Berlin, Germany) ; Medical Faculty of the University of Freiburg (Freiburg, Germany) ; von Bodelschwingh Foundation Bethel, Bielefeld, Germany ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Funding ProjectBMBF[01GQ1705A] ; NSF[BCS-1724243] ; NIH[563386] ; BrainLinks-Brain Tools Cluster of Excellence - German Research Foundation (DFG)[EXC 1086] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32010300] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] ; Natural Science Foundation of China[81422024] ; Natural Science Foundation of China[31771255] ; Else Kroner-Fresenius-Stiftung (Bad Homburg, Germany) ; German Ministry for Economic Affairs and Energy (Berlin, Germany) ; Medical Faculty of the University of Freiburg (Freiburg, Germany) ; von Bodelschwingh Foundation Bethel, Bielefeld, Germany ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[316803389 -SFB 1280] ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[122679504 -SFB 874]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000478770400035
PublisherAMER ASSOC ADVANCEMENT SCIENCE
WOS KeywordNEURAL REPRESENTATIONS ; OSCILLATIONS ; MEMORY ; MECHANISMS ; DISTANCE ; CORTEX ; REWARD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29566
Collection中国科学院心理健康重点实验室
Corresponding AuthorKunz, Lukas; Axmacher, Nikolai
Affiliation1.Univ Freiburg, Fac Med, Med Ctr, Epilepsy Ctr, Freiburg, Germany
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Ruhr Univ Bochum, Fac Psychol, Dept Neuropsychol, Inst Cognit Neurosci, Bochum, Germany
6.Univ Med Ctr, Stereotact & Funct Neurosurg, Freiburg, Germany
7.Beijing Normal Univ, Sch Syst Sci, Beijing, Peoples R China
8.Tsinghua Univ, Yuquan Hosp, Dept Epilepsy Ctr, Beijing, Peoples R China
9.PLA, Affiliated Hosp 1, Dept Neurosurg, Gen Hosp, Beijing, Peoples R China
10.Krankenhaus Mara, Bethel Epilepsy Ctr, Bielefeld, Germany
11.Norwegian Univ Sci & Technol, Kavli Inst Syst Neurosci, Ctr Neural Computat,NTNU, Egil & Pauline Braathen & Fred Kavli Ctr Cort Mic, Trondheim, Norway
Recommended Citation
GB/T 7714
Kunz, Lukas,Wang, Liang,Lachner-Piza, Daniel,et al. Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation[J]. SCIENCE ADVANCES,2019,5(7):17.
APA Kunz, Lukas.,Wang, Liang.,Lachner-Piza, Daniel.,Zhang, Hui.,Brandt, Armin.,...&Axmacher, Nikolai.(2019).Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation.SCIENCE ADVANCES,5(7),17.
MLA Kunz, Lukas,et al."Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation".SCIENCE ADVANCES 5.7(2019):17.
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