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Surface-based regional homogeneity in bipolar disorder: A resting-state fMRI study
Zhang Bo1; Wang Fei2,3; Dong Hao-Ming; Jiang Xiao-Wei2; Wei Sheng-Nan2; Chang Miao2; Yin Zhi-Yang2; Yang Ning3; Zuo Xi-Nian3,4,5; Tang Yan-Qing2; Xu Ke1
First AuthorZhang Bo
Correspondent Emailkxu@cmu.edu.cn (k. xu)
Contribution Rank4
Abstract

Surface-based, two-dimensional regional homogeneity (2dReHo) was used in the current study to compare local functional synchronization of spontaneous neuronal activity between patients with bipolar disorder (BD) and healthy controls (HC), rather than volume-based, three-dimensional regional homogeneity (3dReHo) methods that have been previously described. Seventy-one BD patients and 113 HC participated in structural and resting-state fMRI scans. Participants ranged in age from 12 to 54 years. All subjects were rated with the Young Mania Rating Scale and the Hamilton Depression Rating Scale. BD patients showed reduced surface-based ReHo across the cortical surface, both at the global level and in the left ventral visual stream (VVS). Additionally, ReHo value across the cortical surface showed a significant negative correlation with age in both groups at the global level. Abnormal activity in the left VVS cortex may contribute to the pathogenesis of BD. Therefore, surface-based ReHo may be a useful index to explore the pathophysiology of BD.

KeywordVentral visual stream Regional homogeneity Bipolar disorder Functional magnetic resonance imaging
2019-08-01
Language英语
DOI10.1016/j.psychres.2019.05.045
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
Volume278Pages:199-204
Subtypearticle
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81271499] ; National Natural Science Foundation of China[81571331] ; National Key Research and Development Program[2016YFC1306900] ; National Key Research and Development Program[2016YFC 0904300] ; National High Tech Development Plan (863)[2015AA020513]
PublisherELSEVIER IRELAND LTD
WOS KeywordSCHIZOPHRENIA ; FRAMEWORK ; NETWORK
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000477689600027
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29582
Collection中国科学院行为科学重点实验室
Corresponding AuthorXu Ke
Affiliation1.China Med Univ, Hosp 1, Dept Radiol, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China
2.China Med Univ, Hosp 1, Dept Radiol & Psychiat, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Zhang Bo,Wang Fei,Dong Hao-Ming,et al. Surface-based regional homogeneity in bipolar disorder: A resting-state fMRI study[J]. PSYCHIATRY RESEARCH,2019,278:199-204.
APA Zhang Bo.,Wang Fei.,Dong Hao-Ming.,Jiang Xiao-Wei.,Wei Sheng-Nan.,...&Xu Ke.(2019).Surface-based regional homogeneity in bipolar disorder: A resting-state fMRI study.PSYCHIATRY RESEARCH,278,199-204.
MLA Zhang Bo,et al."Surface-based regional homogeneity in bipolar disorder: A resting-state fMRI study".PSYCHIATRY RESEARCH 278(2019):199-204.
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