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Inheritance of Neural Substrates for Motivation and Pleasure
Li, Zhi1,2; Wang, Yi1; Yan, Chao3; Cheung, Eric F. C.4; Docherty, Anna R.5,6; Sham, Pak C.7,8,9; Gur, Raquel E.10; Gur, Ruben C.10; Chan, Raymond C. K.1,2
First AuthorLi, Zhi
Contribution Rank1

Despite advances in the understanding of the reward system and the role of dopamine in recent decades, the heritability of the underlying neural mechanisms is not known. In the present study, we examined the hemodynamic activation of the nucleus accumbens (NAcc), a key hub of the reward system, in 86 healthy monozygotic twins and 88 healthy dizygotic twins during a monetary-incentive-delay task. The participants also completed self-report measures of pleasure. Using voxelwise heritability mapping, we found that activation of the bilateral NAcc during the anticipation of monetary gains had significant heritability (h(2) = .20-.49). Moreover, significant shared genetic covariance was observed between pleasure and NAcc activation during the anticipation of monetary gain. These findings suggest that both NAcc activation and self-reported pleasure may be heritable and that their phenotypic correlation may be partially explained by shared genetic variation.

Keywordreward system nucleus accumbens heritability motivation pleasure
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; National Natural Science Foundation of China[81571317] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; Beijing Municipal Commission of Science and Technology[Z161100000216138] ; Chinese Academy of Sciences (CAS)[XDB02030002] ; CAS Key Laboratory of Mental Health at the Institute of Psychology ; CAS/State Administration of Foreign Experts Affairs (SAFEA) International Partnership Program for Creative Research Teams[Y2CX131003]
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000477166500001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.East China Normal Univ, Sch Psychol & Cognit Sci, Key Lab Brain Funct Genom, Shanghai, Peoples R China
4.Castle Peak Hosp, Hong Kong, Peoples R China
5.Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
6.Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23284 USA
7.Univ Hong Kong, Ctr Genom Sci, Hong Kong, Peoples R China
8.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China
9.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
10.Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Li, Zhi,Wang, Yi,Yan, Chao,et al. Inheritance of Neural Substrates for Motivation and Pleasure[J]. PSYCHOLOGICAL SCIENCE,2019,30(8):1205-1217.
APA Li, Zhi.,Wang, Yi.,Yan, Chao.,Cheung, Eric F. C..,Docherty, Anna R..,...&Chan, Raymond C. K..(2019).Inheritance of Neural Substrates for Motivation and Pleasure.PSYCHOLOGICAL SCIENCE,30(8),1205-1217.
MLA Li, Zhi,et al."Inheritance of Neural Substrates for Motivation and Pleasure".PSYCHOLOGICAL SCIENCE 30.8(2019):1205-1217.
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