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Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students
Chen, Zheng1,2,3; Zhang, Quan1,2,3; Chen, Shenghuo1,2,3; Wang, Weiwen4; Liu, Guoxiong5; Deng, Huihua1,2,3,4
First AuthorChen, Zheng
2019-09-01
Source PublicationSTEROIDS
Correspondent Emaildengrcls@seu.edu.cn (h. deng)
ISSN0039-128X
Subtypearticle
Volume149Pages:10
Contribution Rank2
Abstract

Hair steroids and their ratios are believed to be reliable biomarkers reflecting the long-term exposure of circulating steroids. Hereinto, two underlying assumptions are that hair biomarkers have consistency with traditional biomarkers in saliva or urine, and good long-term intraindividual stability across a long time. However, these two assumptions have not been well verified for most of hair biomarkers except for hair cortisol. Thus, this study aimed to verify the two issues on eight hair biomarkers: cortisol, cortisone, dehydroepiandrosterone (DHEA), testosterone, progesterone, the ratios of cortisol to cortisone, DHEA and testosterone. The five steroids in hair, saliva and urine were measured with high performance chromatography tandem mass spectrometry. The results revealed that the hair biomarkers had significant correlations with the salivary biomarkers calculated by the mean area under curve (AUCg) in a matched time span (ps < 0.05) where the coefficients of correlations (r) were > 0.3 (r = 0.322-0.616) except cortisone and progesterone (r = 0.177 and 0.212, respectively). It indicated that hair biomarkers had weak to moderate consistency with salivary ones. But only three biomarkers showed the consistency between hair and urine, such as testosterone (r = 0.352, p < 0.01), progesterone (r = 0.228, p < 0.05) and the ratio of cortisol to testosterone (r = 0.502, p < 0.01). Hair biomarkers showed no absolute stability, but moderate to high long-term relative stability across 12 months where interclass correlation coefficients ranged between 0.356 and 0.678 (ps < 0.01). These results implied that the eight biomarkers in hair could retrospectively reflect their cumulative exposure in vivo. Therefore, the hair biomarkers would be considerable reliable long-term biomarkers for psychological and physiological research.

KeywordHair steroids Determination Intercorrelation Intraindividual stability
DOI10.1016/j.steroids.2019.05.010
Indexed BySCI
Language英语
Funding OrganizationInstitute of Moral Education Research, the Key Research Center of the Humanities and Social Science of Ministry of Education China ; Humanities and Social Science Foundation of Ministry of Education ; National Basic Research Program of China ; Jiangsu Provincial Innovation Project for Scientific Research of Graduate Students in Universities ; Fundamental Research Funds of the Central universities for the Southeast University ; program for New Century Excellent Talents in University, Ministry of Education ; China Scholarship Council
Funding ProjectInstitute of Moral Education Research, the Key Research Center of the Humanities and Social Science of Ministry of Education China[DYS20170601] ; Humanities and Social Science Foundation of Ministry of Education[15YJAZH009] ; National Basic Research Program of China[2015CB351704] ; Jiangsu Provincial Innovation Project for Scientific Research of Graduate Students in Universities[KYZZ14_0069] ; Jiangsu Provincial Innovation Project for Scientific Research of Graduate Students in Universities[KYZZ15_0054] ; Fundamental Research Funds of the Central universities for the Southeast University[3250184903] ; Fundamental Research Funds of the Central universities for the Southeast University[3250185703] ; Fundamental Research Funds of the Central universities for the Southeast University[3218006405] ; program for New Century Excellent Talents in University, Ministry of Education[NCET-08-0122] ; China Scholarship Council[201506090143]
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000477788300010
PublisherELSEVIER SCIENCE INC
WOS KeywordACUTE PSYCHOSOCIAL STRESS ; DEHYDROEPIANDROSTERONE DHEA ; TESTOSTERONE LEVELS ; SEASONAL-VARIATION ; MAJOR DEPRESSION ; DIURNAL PATTERNS ; CORTISOL-LEVELS ; LEYDIG-CELLS ; PROGESTERONE ; MEN
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29600
Collection中国科学院心理健康重点实验室
Corresponding AuthorDeng, Huihua
Affiliation1.Southeast Univ, Minist Educ, Key Lab Child Dev & Learning Sci, Nanjing 210096, Jiangsu, Peoples R China
2.Southeast Univ, Inst Child Dev & Educ, Nanjing 210096, Jiangsu, Peoples R China
3.Southeast Univ, Sch Biol Sci & Med Engn, Dept Brain & Learning Sci, Nanjing 210096, Jiangsu, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Nanjing Normal Univ, Sch Psychol, Nanjing 210097, Jiangsu, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chen, Zheng,Zhang, Quan,Chen, Shenghuo,et al. Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students[J]. STEROIDS,2019,149:10.
APA Chen, Zheng,Zhang, Quan,Chen, Shenghuo,Wang, Weiwen,Liu, Guoxiong,&Deng, Huihua.(2019).Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students.STEROIDS,149,10.
MLA Chen, Zheng,et al."Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students".STEROIDS 149(2019):10.
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