Altered transposition asymmetry in serial ordering in early Parkinson's disease | |
Ma, Shaoyang1,2; Zhang, Yingshuang3; Liu, Na3; Xiao, Weizhong3; Li, Shuaiqi4; Zhang, Guanyu1,2; Zhou, Xiaolin4,5; Muente, Thomas F.6; Ye, Zheng7![]() | |
First Author | Ma, Shaoyang |
2019-05-01 | |
Source Publication | PARKINSONISM & RELATED DISORDERS
![]() |
Correspondent Email | thomas.muente@neuro.uni-luebeck.de (t.f. münte) ; yez@ion.ac.cn (z. ye) |
ISSN | 1353-8020 |
Subtype | article |
Volume | 62Pages:62-67 |
Contribution Rank | 1 |
Abstract | Introduction: The ability to arrange thoughts and actions in an appropriate serial order is impaired in Parkinson's disease (PD). However, it is unclear how serial order is represented and manipulated and how the representation or manipulation is altered in the early stages of PD. We aimed to analyze the pattern of performance errors in serial ordering versus serial recall in nondemented PD patients with mild clinical symptoms and healthy adults to identify the underlying principles of serial ordering. Methods: PD patients (N = 57) and healthy controls (N = 40) completed the adaptive digit ordering and digit span forward tests. We focused on items recalled in incorrect positions (transposition) and analyzed the tendency to recall transposed items too early (anticipation) versus too late (postponement). We also analyzed the tendency to recall the item displaced by the error (fill-in) versus the item following the error in the target output order (infill) after anticipation errors. Results: PD patients not only made more transposition errors but also showed distinct error patterns. The patients made more anticipations but not postponements, and more fill-ins but not in fills than healthy controls in the ordering test (transposition asymmetry). Individual patients' percentage of anticipations was negatively correlated with their daily exposure to D2/3 receptor agonists. Patients' error pattern in the forward test was normal. Conclusion: The increase in anticipations in PD suggests an increase in the forward-specific variability in the representation of serial order. Their increase in fill-ins suggests a deficit in the chaining mechanism involved in the manipulation of serial order. |
Keyword | Parkinson's disease D2/3 receptor Serial ordering Anticipation Fill-in |
DOI | 10.1016/j.parkreldis.2019.01.028 |
Indexed By | SCI |
Language | 英语 |
Funding Organization | National Natural Science Foundation of China ; Thousand Young Talents Program ; Alexander von Humboldt Foundation ; German Research Foundation |
Funding Project | National Natural Science Foundation of China[31771216] ; Thousand Young Talents Program ; Alexander von Humboldt Foundation ; German Research Foundation[SFB TR134 C1] |
WOS Research Area | Neurosciences & Neurology |
WOS Subject | Clinical Neurology |
WOS ID | WOS:000476961700010 |
Publisher | ELSEVIER SCI LTD |
WOS Keyword | WORKING-MEMORY ; COGNITIVE IMPAIRMENT ; MODEL ; COMPREHENSION ; DEFICITS ; TASK |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/29603 |
Collection | 健康与遗传心理学研究室 |
Corresponding Author | Muente, Thomas F.; Ye, Zheng |
Affiliation | 1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Peking Univ, Hosp 3, Dept Neurol, Beijing, Peoples R China 4.Peking Univ, Sch Psychol & Cognit Sci, Ctr Brain & Cognit Sci, Beijing, Peoples R China 5.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China 6.Univ Lubeck, Dept Neurol, Ratzeburger Allee 160, D-23538 Lubeck, Germany 7.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci,Key Lab Primate Neurobiol, Shanghai, Peoples R China |
Recommended Citation GB/T 7714 | Ma, Shaoyang,Zhang, Yingshuang,Liu, Na,et al. Altered transposition asymmetry in serial ordering in early Parkinson's disease[J]. PARKINSONISM & RELATED DISORDERS,2019,62:62-67. |
APA | Ma, Shaoyang.,Zhang, Yingshuang.,Liu, Na.,Xiao, Weizhong.,Li, Shuaiqi.,...&Ye, Zheng.(2019).Altered transposition asymmetry in serial ordering in early Parkinson's disease.PARKINSONISM & RELATED DISORDERS,62,62-67. |
MLA | Ma, Shaoyang,et al."Altered transposition asymmetry in serial ordering in early Parkinson's disease".PARKINSONISM & RELATED DISORDERS 62(2019):62-67. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
Altered transpositio(650KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment