PSYCH OpenIR  > 中国科学院心理健康重点实验室
Alternative TitleNeural Oscillations Underlying The Extinction of Conditioned Fear Memory
夏文然; 陈思; 王亮
First Author夏文然
Contribution Rank1
Other AbstractAs part of the self-protection mechanism that individuals use to deal with internal and external risk factors, fear plays an important role in the survival of organisms. However, excessive fear is not only detrimental to the survival of the individual, but also easy to cause mental illness such as post-traumatic stress disorder and anxiety, which seriously affects the quality of life. Clinically, exposure therapy based on behavioral findings is often used to treat fear-related diseases, but these symptoms often recur when the patient break away from the treatment environment. Therefore, the investigation of the information processing in the neural circuits related to fear memory is essential for understanding the occurrence and development of these diseases and establishing new treatments. Numerous studies have demonstrated that the brain regions associated with the extinction of fear memory mainly include the amygdala, medial prefrontal cortex and hippocampus. In the process of fear extinction, these three brain regions show specific patterns of neural oscillations, and their activities are also synchronized, which constitute the neural basis for the successful extinction of fear memory.In the future, noninvasive brain stimulation based on oscillatory entrainment can be used to intervene the neural circuit and promote the extinction of fear memory and avoid the recurrence of fear, which provides new insights into the treatment of clinical fear-related disorders.
Keyword恐惧消退 恐惧记忆 神经振荡 神经环路
Source Publication生物化学与生物物理进展
Project Intro.北京市科学技术委员会资助项目(Z171100000117014);; 国家重点研发计划资助项目(2016YFC1307200);; 中国科学院战略性先导科技专项(B类)(XDB32010300)资助~~
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Document Type期刊论文
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夏文然,陈思,王亮. 条件化恐惧记忆消退的神经振荡机制[J]. 生物化学与生物物理进展,2019,46(03):276-286.
APA 夏文然,陈思,&王亮.(2019).条件化恐惧记忆消退的神经振荡机制.生物化学与生物物理进展,46(03),276-286.
MLA 夏文然,et al."条件化恐惧记忆消退的神经振荡机制".生物化学与生物物理进展 46.03(2019):276-286.
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