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Alternative TitleRole of the central interleukin-1 in stress responses
郑瑞茂; 祝世功
Source Publication生理学报
Abstract白细胞介素-1(interleukin-1,IL-1)系统分子广泛分布于中枢神经系统。中枢IL-1具有极其丰富的生物学功能,作为经典炎性细胞因子,在多种生理、病理生理过程中起重要作用。近几年来,中枢IL-1的应激介质作用备受关注。本文综述了中枢IL-1在应激反应中作用的最新进展,包括应激对中枢IL-1系统的影响,中枢IL-1对应激反应的启动和介导作用; 参与中枢IL-1应激介导作用的神经环路和细胞信号转导通路,以及中枢IL-1对应激时脑高级功能和行为反应的影响。
Keyword白细胞介素 -1 中枢神经系统 应激
Subject Area生理心理学
Indexed By中文核心期刊要目总览 ASPT来源刊 中国期刊方阵 CJFD收录刊
Funding ProjectNational Basic Research Priorities Programme of China (No. G2000056908) and the National Natural Science Foundation of China (No. 3980047, 30370557)
NoteThe molecules of interleukin-1 (IL-1) system are widely distributed in central nervous system. As a classical pro-inflammatory factor, central IL-1 has diverse biological functions and plays a pivotal role in a number of important physiological and pathophysiological processes. During the past few years, particular attentions have been directed to the stress mediator actions of central IL-1. This paper reviews some recent findings in the studies of central IL-1 functions in stress responses, including the effects of stress on central IL-1, the roles of IL-1 in the initiation of stress responses, the neural circuitries and intracellular signal transduction pathways involved in the central IL-1 mediated stress responses, as well as the actions of central IL-1 on brain high function and behavior under stressful conditions.
Document Type期刊论文
Corresponding Author祝世功
Recommended Citation
GB/T 7714
郑瑞茂,祝世功. 中枢白细胞介素-1在应激反应中的作用(英文)[J]. 生理学报,2005,57(4):414-420.
APA 郑瑞茂,&祝世功.(2005).中枢白细胞介素-1在应激反应中的作用(英文).生理学报,57(4),414-420.
MLA 郑瑞茂,et al."中枢白细胞介素-1在应激反应中的作用(英文)".生理学报 57.4(2005):414-420.
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