Institutional Repository of Key Laboratory of Behavioral Science, CAS
Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study | |
Chen, Xiaoming1; Li, Hong2,3; Zhang, Qian1; Wang, Jiye1; Zhang, Wenbin1; Liu, Jian4; Li, Baojuan5; Xin, Zhenlong1; Liu, Jie6; Yin, Hong7; Chen, Jingyuan1; Kong, Yazhuo2,3; Luo, Wenjing1 | |
第一作者 | Xiaoming Chen1 |
通讯作者邮箱 | jy_chen@fmmu.edu.cn |
心理所单位排序 | 2 |
摘要 | The study of individuals at high-altitude (HA) exposure provides an important opportunity for unraveling physiological and psychological mechanism of brain underlying hypoxia condition. However, this has rarely been assessed longitudinally. We aim to explore the cognitive and cerebral microstructural alterations after chronic HA exposure. We recruited 49 college freshmen who immigrated to Tibet and followed up for 2 years. Control group consisted of 49 gender and age-matched subjects from sea level. Neuropsychological tests were also conducted to determine whether the subjects' cognitive function had changed in response to chronic HA exposure. Surface-based cortical and subcortical volumes were calculated from structural magnetic resonance imaging data, and tract-based spatial statistics (TBSS) analysis of white matter (WM) fractional anisotropy (FA) based on diffusion weighted images were performed. Compared to healthy controls, the high-altitude exposed individuals showed significantly lower accuracy and longer reaction times in memory tests. Significantly decreased gray matter volume in the caudate region and significant FA changes in multiple WM tracts were observed for HA immigrants. Furthermore, differences in subcortical volume and WM integration were found to be significantly correlated with the cognitive changes after 2 years' HA exposure. Cognitive functions such as working memory and psychomotor function were found to be impaired during chronic HA. Differences of brain subcortical volumes and WM integration between HA and sea-level participants indicated potential impairments in the brain structural modifications and microstructural integrity of WM tracts after HA exposure. |
关键词 | cognition fractional anisotropy high-altitude exposure subcortical volume |
2019-10-01 | |
语种 | 英语 |
DOI | 10.1002/hbm.24696 |
发表期刊 | HUMAN BRAIN MAPPING |
ISSN | 1065-9471 |
卷号 | 40期号:14页码:4202-4212 |
期刊论文类型 | article |
收录类别 | SCI |
出版者 | WILEY |
WOS关键词 | WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; NEUROIMAGING CHANGES ; PREFRONTAL CORTEX ; CEREBRAL-CORTEX ; DIFFUSION ; HIPPOCAMPUS ; ADAPTATION ; EXPOSURE ; HYPOXIA |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000482454100014 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/29757 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Chen, Jingyuan; Kong, Yazhuo; Luo, Wenjing |
作者单位 | 1.Air Force Med Univ, Sch Publ Hlth, Key Lab Hazard Assessment & Control Special Opera, Minist Educ,Dept Occupat & Environm Hlth, Xian, Shaanxi, Peoples R China 2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Air Force Med Univ, Network Ctr, Xian, Shaanxi, Peoples R China 5.Air Force Med Univ, Sch Biomed Engn, Xian, Shaanxi, Peoples R China 6.Air Force Med Univ, Xijing Hosp, Dept Radiol, Xian, Shaanxi, Peoples R China 7.Gen Hosp Tibet Mil Reg, Dept Radiol, Lhasa, Peoples R China |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Chen, Xiaoming,Li, Hong,Zhang, Qian,et al. Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study[J]. HUMAN BRAIN MAPPING,2019,40(14):4202-4212. |
APA | Chen, Xiaoming.,Li, Hong.,Zhang, Qian.,Wang, Jiye.,Zhang, Wenbin.,...&Luo, Wenjing.(2019).Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study.HUMAN BRAIN MAPPING,40(14),4202-4212. |
MLA | Chen, Xiaoming,et al."Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study".HUMAN BRAIN MAPPING 40.14(2019):4202-4212. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Combined fractional (1214KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论