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Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study
Chen, Xiaoming1; Li, Hong2,3; Zhang, Qian1; Wang, Jiye1; Zhang, Wenbin1; Liu, Jian4; Li, Baojuan5; Xin, Zhenlong1; Liu, Jie6; Yin, Hong7; Chen, Jingyuan1; Kong, Yazhuo2,3; Luo, Wenjing1
First AuthorXiaoming Chen1
2019-10-01
Source PublicationHUMAN BRAIN MAPPING
Correspondent Emailjy_chen@fmmu.edu.cn
ISSN1065-9471
Subtypearticle
Volume40Issue:14Pages:4202-4212
Contribution Rank2
Abstract

The study of individuals at high-altitude (HA) exposure provides an important opportunity for unraveling physiological and psychological mechanism of brain underlying hypoxia condition. However, this has rarely been assessed longitudinally. We aim to explore the cognitive and cerebral microstructural alterations after chronic HA exposure. We recruited 49 college freshmen who immigrated to Tibet and followed up for 2 years. Control group consisted of 49 gender and age-matched subjects from sea level. Neuropsychological tests were also conducted to determine whether the subjects' cognitive function had changed in response to chronic HA exposure. Surface-based cortical and subcortical volumes were calculated from structural magnetic resonance imaging data, and tract-based spatial statistics (TBSS) analysis of white matter (WM) fractional anisotropy (FA) based on diffusion weighted images were performed. Compared to healthy controls, the high-altitude exposed individuals showed significantly lower accuracy and longer reaction times in memory tests. Significantly decreased gray matter volume in the caudate region and significant FA changes in multiple WM tracts were observed for HA immigrants. Furthermore, differences in subcortical volume and WM integration were found to be significantly correlated with the cognitive changes after 2 years' HA exposure. Cognitive functions such as working memory and psychomotor function were found to be impaired during chronic HA. Differences of brain subcortical volumes and WM integration between HA and sea-level participants indicated potential impairments in the brain structural modifications and microstructural integrity of WM tracts after HA exposure.

Keywordcognition fractional anisotropy high-altitude exposure subcortical volume
DOI10.1002/hbm.24696
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000482454100014
PublisherWILEY
WOS KeywordWORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; NEUROIMAGING CHANGES ; PREFRONTAL CORTEX ; CEREBRAL-CORTEX ; DIFFUSION ; HIPPOCAMPUS ; ADAPTATION ; EXPOSURE ; HYPOXIA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29757
Collection中国科学院行为科学重点实验室
Corresponding AuthorChen, Jingyuan; Kong, Yazhuo; Luo, Wenjing
Affiliation1.Air Force Med Univ, Sch Publ Hlth, Key Lab Hazard Assessment & Control Special Opera, Minist Educ,Dept Occupat & Environm Hlth, Xian, Shaanxi, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Air Force Med Univ, Network Ctr, Xian, Shaanxi, Peoples R China
5.Air Force Med Univ, Sch Biomed Engn, Xian, Shaanxi, Peoples R China
6.Air Force Med Univ, Xijing Hosp, Dept Radiol, Xian, Shaanxi, Peoples R China
7.Gen Hosp Tibet Mil Reg, Dept Radiol, Lhasa, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xiaoming,Li, Hong,Zhang, Qian,et al. Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study[J]. HUMAN BRAIN MAPPING,2019,40(14):4202-4212.
APA Chen, Xiaoming.,Li, Hong.,Zhang, Qian.,Wang, Jiye.,Zhang, Wenbin.,...&Luo, Wenjing.(2019).Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study.HUMAN BRAIN MAPPING,40(14),4202-4212.
MLA Chen, Xiaoming,et al."Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study".HUMAN BRAIN MAPPING 40.14(2019):4202-4212.
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