Institutional Repository of Key Laboratory of Mental Health, CAS
Prevalence and clinical profiles of comorbid anxiety in first episode and drug naive patients with major depressive disorder | |
Yang, Wanqiu1; Zhang, Guangya2; Jia, Qiufang2; Qian, Zheng-Kang2; Yin, Guangzhong2; Zhu, Xiaomin2; Alnatour, Omar, I3; Trinh, Tammy H.3; Wu, Hanjing Emily3; Lang, XiaoE4; Du, Xiangdong2; Zhang, Xiangyang5,6 | |
第一作者 | Yang, Wanqiu |
通讯作者邮箱 | xiangdong-du@163.com (x. du) ; zhangxy@psych.ac.cn (x. zhang) |
心理所单位排序 | 5 |
摘要 | Background Anxiety is a common comorbidity in major depressive disorder (MDD) that has been studied extensively in the past. However, few studies have explored anxiety in drug naive (FEDN) patients with MDD and those presenting with a first episode. The objective of this current study was to examine the prevalence and risk factors of anxiety in FEDN patients with MDD in order to understand the relationship between MDD and anxiety in the acute early phase and provide important implications for therapeutic interventions. Methods: A total of 1718 FEDN patients with MDD were recruited in this cross-sectional study. Their anthropometric and clinical data, including suicide attempt and psychotic symptom, were collected. The Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were used to evaluate depression and anxiety for all the patients in this study. Results: Overall, we found that the prevalence of anxiety in FEDN MDD patients was 80.3%. Correlation analysis showed that anxiety was associated with suicide attempt and psychotic symptom in FEDN patients with MDD. The rate of suicide attempt and psychosis in above patients with anxiety was 24.3% and 12.3%, respectively. Furthermore, stepwise regression analysis showed that suicide attempt and psychotic symptom were significant predictors for anxiety in FEDN patients with MDD. Conclusions: Our study showed that the prevalence of comorbid anxiety in FEDN patients with MDD is very high. We also found that two clinical variables, suicide attempt and psychosis, are risk factors for comorbid anxiety in FEDN patients with MDD. |
2019-10-01 | |
语种 | 英语 |
DOI | 10.1016/j.jad.2019.06.052 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 257页码:200-206 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | Double Top of Yunnan University, National Key R&D Program of China[2017YFE0103700] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Key Diagnosis and treatment Program of Suzhou[LCZX201615] |
出版者 | ELSEVIER |
WOS关键词 | MENTAL-DISORDERS ; NONANXIOUS DEPRESSION ; ANXIOUS DEPRESSION ; PSYCHOTIC FEATURES ; CO-MORBIDITY ; OUTPATIENTS ; DISABILITY ; SYMPTOMS ; CHINA ; DIFFERENCE |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000482376300028 |
资助机构 | Double Top of Yunnan University, National Key R&D Program of China ; Suzhou Key Medical Center for Psychiatric Diseases ; Key Diagnosis and treatment Program of Suzhou |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/29781 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Du, Xiangdong; Zhang, Xiangyang |
作者单位 | 1.Yunnan Univ, Mental Hlth Ctr, Kunming, Yunnan, Peoples R China 2.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, 286 Guangji Rd, Suzhou, Jiangsu, Peoples R China 3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 4.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Yang, Wanqiu,Zhang, Guangya,Jia, Qiufang,et al. Prevalence and clinical profiles of comorbid anxiety in first episode and drug naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,257:200-206. |
APA | Yang, Wanqiu.,Zhang, Guangya.,Jia, Qiufang.,Qian, Zheng-Kang.,Yin, Guangzhong.,...&Zhang, Xiangyang.(2019).Prevalence and clinical profiles of comorbid anxiety in first episode and drug naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,257,200-206. |
MLA | Yang, Wanqiu,et al."Prevalence and clinical profiles of comorbid anxiety in first episode and drug naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 257(2019):200-206. |
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