PSYCH OpenIR  > 中国科学院心理健康重点实验室
Prevalence and clinical profiles of comorbid anxiety in first episode and drug naive patients with major depressive disorder
Yang, Wanqiu1; Zhang, Guangya2; Jia, Qiufang2; Qian, Zheng-Kang2; Yin, Guangzhong2; Zhu, Xiaomin2; Alnatour, Omar, I3; Trinh, Tammy H.3; Wu, Hanjing Emily3; Lang, XiaoE4; Du, Xiangdong2; Zhang, Xiangyang5,6
First AuthorYang, Wanqiu
2019-10-01
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
Correspondent Emailxiangdong-du@163.com (x. du) ; zhangxy@psych.ac.cn (x. zhang)
ISSN0165-0327
Subtypearticle
Volume257Pages:200-206
Contribution Rank5
Abstract

Background Anxiety is a common comorbidity in major depressive disorder (MDD) that has been studied extensively in the past. However, few studies have explored anxiety in drug naive (FEDN) patients with MDD and those presenting with a first episode. The objective of this current study was to examine the prevalence and risk factors of anxiety in FEDN patients with MDD in order to understand the relationship between MDD and anxiety in the acute early phase and provide important implications for therapeutic interventions. Methods: A total of 1718 FEDN patients with MDD were recruited in this cross-sectional study. Their anthropometric and clinical data, including suicide attempt and psychotic symptom, were collected. The Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were used to evaluate depression and anxiety for all the patients in this study. Results: Overall, we found that the prevalence of anxiety in FEDN MDD patients was 80.3%. Correlation analysis showed that anxiety was associated with suicide attempt and psychotic symptom in FEDN patients with MDD. The rate of suicide attempt and psychosis in above patients with anxiety was 24.3% and 12.3%, respectively. Furthermore, stepwise regression analysis showed that suicide attempt and psychotic symptom were significant predictors for anxiety in FEDN patients with MDD. Conclusions: Our study showed that the prevalence of comorbid anxiety in FEDN patients with MDD is very high. We also found that two clinical variables, suicide attempt and psychosis, are risk factors for comorbid anxiety in FEDN patients with MDD.

DOI10.1016/j.jad.2019.06.052
Indexed BySCI
Language英语
Funding OrganizationDouble Top of Yunnan University, National Key R&D Program of China ; Suzhou Key Medical Center for Psychiatric Diseases ; Key Diagnosis and treatment Program of Suzhou
Funding ProjectDouble Top of Yunnan University, National Key R&D Program of China[2017YFE0103700] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Key Diagnosis and treatment Program of Suzhou[LCZX201615]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000482376300028
PublisherELSEVIER
WOS KeywordMENTAL-DISORDERS ; NONANXIOUS DEPRESSION ; ANXIOUS DEPRESSION ; PSYCHOTIC FEATURES ; CO-MORBIDITY ; OUTPATIENTS ; DISABILITY ; SYMPTOMS ; CHINA ; DIFFERENCE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29781
Collection中国科学院心理健康重点实验室
Corresponding AuthorDu, Xiangdong; Zhang, Xiangyang
Affiliation1.Yunnan Univ, Mental Hlth Ctr, Kunming, Yunnan, Peoples R China
2.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, 286 Guangji Rd, Suzhou, Jiangsu, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yang, Wanqiu,Zhang, Guangya,Jia, Qiufang,et al. Prevalence and clinical profiles of comorbid anxiety in first episode and drug naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,257:200-206.
APA Yang, Wanqiu.,Zhang, Guangya.,Jia, Qiufang.,Qian, Zheng-Kang.,Yin, Guangzhong.,...&Zhang, Xiangyang.(2019).Prevalence and clinical profiles of comorbid anxiety in first episode and drug naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,257,200-206.
MLA Yang, Wanqiu,et al."Prevalence and clinical profiles of comorbid anxiety in first episode and drug naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 257(2019):200-206.
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