PSYCH OpenIR  > 中国科学院心理健康重点实验室
Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms
Wang, Yong-ming1,2,3,4; Cai, Xin-lu1,2,3,4; Zhang, Rui-ting1,4; Wang, Yi1,4; Madsen, Kristoffer Hougaard3,5,6; Sorensen, Thomas Alrik3,7; Moller, Arne3,8,9; Cheung, Eric F. C.10; Chan, Raymond C. K.1,2,3,4
第一作者Yong-ming Wang
通讯作者邮箱raymond c. k. chan rckchan@psych.ac.cn
心理所单位排序1
摘要

Introduction Investigating obsessive-compulsive symptoms in subclinical populations provides a useful framework for understanding the early development of obsessive-compulsive spectrum disorders. The present study aimed to apply searchlight classification analysis on resting-state functional magnetic resonance imaging data to identify potential brain markers in subclinical individuals with obsessive-compulsive symptoms. Methods In this observational study, 40 college students with high obsessive-compulsive symptom scores and 40 with low obsessive-compulsive symptom scores were recruited from universities in China. We conducted searchlight classification and comparison analysis between the two groups based on Amplitude of Low Frequency Fluctuation (ALFF), fraction ALFF (fALFF) and resting-state functional connectivity using searchlight classification. Results We found that the highest accuracy rate in differentiating between the two groups was 85.00%. Significant discriminating features included the ALFF of the left medial superior frontal gyrus and the functional connectivity between the right thalamus and the bilateral medial superior frontal gyrus, and the right putamen, as well as the functional connectivity between the left caudate and the right insula. Conclusions These findings highlight the specific and distinguishing brain functional abnormalities associated with obsessive-compulsive symptoms.

关键词Obsessive-compulsive symptoms searchlight Amplitude of Low Frequency Fluctuation functional connectivity
2019-08-28
语种英语
DOI10.1080/13546805.2019.1658575
发表期刊COGNITIVE NEUROPSYCHIATRY (IF:1.700[JCR-2022],1.900[5-Year])
ISSN1354-6805
页码13
期刊论文类型article
收录类别SCI
资助项目National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology
出版者ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
WOS关键词GENOME-WIDE ASSOCIATION ; PERSONALITY-TRAITS ; DISORDER EVIDENCE ; TENDENCIES ; FMRI ; INVENTORY ; NEUROPSYCHOLOGY ; VALIDATION ; ACTIVATION ; CIRCUITS
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000483718100001
资助机构National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for the Leading Talents in S T ; Chinese Academy of Science ; CAS Key Laboratory of Mental Health, Institute of Psychology
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://ir.psych.ac.cn/handle/311026/29800
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Copenhagen Univ Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark
6.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
7.Aalborg Univ, Dept Commun & Psychol, Ctr Cognit Neurosci, Aalborg, Denmark
8.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark
9.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
10.Castle Peak Hosp, Hong Kong, Peoples R China
第一作者单位认知与发展心理学研究室
通讯作者单位认知与发展心理学研究室
推荐引用方式
GB/T 7714
Wang, Yong-ming,Cai, Xin-lu,Zhang, Rui-ting,et al. Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms[J]. COGNITIVE NEUROPSYCHIATRY,2019:13.
APA Wang, Yong-ming.,Cai, Xin-lu.,Zhang, Rui-ting.,Wang, Yi.,Madsen, Kristoffer Hougaard.,...&Chan, Raymond C. K..(2019).Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms.COGNITIVE NEUROPSYCHIATRY,13.
MLA Wang, Yong-ming,et al."Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms".COGNITIVE NEUROPSYCHIATRY (2019):13.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Searchlight classifi(1430KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yong-ming]的文章
[Cai, Xin-lu]的文章
[Zhang, Rui-ting]的文章
百度学术
百度学术中相似的文章
[Wang, Yong-ming]的文章
[Cai, Xin-lu]的文章
[Zhang, Rui-ting]的文章
必应学术
必应学术中相似的文章
[Wang, Yong-ming]的文章
[Cai, Xin-lu]的文章
[Zhang, Rui-ting]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。