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Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms
Wang, Yong-ming1,2,3,4; Cai, Xin-lu1,2,3,4; Zhang, Rui-ting1,4; Wang, Yi1,4; Madsen, Kristoffer Hougaard3,5,6; Sorensen, Thomas Alrik3,7; Moller, Arne3,8,9; Cheung, Eric F. C.10; Chan, Raymond C. K.1,2,3,4
First AuthorYong-ming Wang
2019-08-28
Source PublicationCOGNITIVE NEUROPSYCHIATRY
Correspondent Emailraymond c. k. chan rckchan@psych.ac.cn
ISSN1354-6805
Subtypearticle
Pages13
Contribution Rank1
Abstract

Introduction Investigating obsessive-compulsive symptoms in subclinical populations provides a useful framework for understanding the early development of obsessive-compulsive spectrum disorders. The present study aimed to apply searchlight classification analysis on resting-state functional magnetic resonance imaging data to identify potential brain markers in subclinical individuals with obsessive-compulsive symptoms. Methods In this observational study, 40 college students with high obsessive-compulsive symptom scores and 40 with low obsessive-compulsive symptom scores were recruited from universities in China. We conducted searchlight classification and comparison analysis between the two groups based on Amplitude of Low Frequency Fluctuation (ALFF), fraction ALFF (fALFF) and resting-state functional connectivity using searchlight classification. Results We found that the highest accuracy rate in differentiating between the two groups was 85.00%. Significant discriminating features included the ALFF of the left medial superior frontal gyrus and the functional connectivity between the right thalamus and the bilateral medial superior frontal gyrus, and the right putamen, as well as the functional connectivity between the left caudate and the right insula. Conclusions These findings highlight the specific and distinguishing brain functional abnormalities associated with obsessive-compulsive symptoms.

KeywordObsessive-compulsive symptoms searchlight Amplitude of Low Frequency Fluctuation functional connectivity
DOI10.1080/13546805.2019.1658575
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Programme ; Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for the Leading Talents in S T ; Chinese Academy of Science ; CAS Key Laboratory of Mental Health, Institute of Psychology
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000483718100001
PublisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
WOS KeywordGENOME-WIDE ASSOCIATION ; PERSONALITY-TRAITS ; DISORDER EVIDENCE ; TENDENCIES ; FMRI ; INVENTORY ; NEUROPSYCHOLOGY ; VALIDATION ; ACTIVATION ; CIRCUITS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29800
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Copenhagen Univ Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark
6.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
7.Aalborg Univ, Dept Commun & Psychol, Ctr Cognit Neurosci, Aalborg, Denmark
8.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark
9.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
10.Castle Peak Hosp, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yong-ming,Cai, Xin-lu,Zhang, Rui-ting,et al. Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms[J]. COGNITIVE NEUROPSYCHIATRY,2019:13.
APA Wang, Yong-ming.,Cai, Xin-lu.,Zhang, Rui-ting.,Wang, Yi.,Madsen, Kristoffer Hougaard.,...&Chan, Raymond C. K..(2019).Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms.COGNITIVE NEUROPSYCHIATRY,13.
MLA Wang, Yong-ming,et al."Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms".COGNITIVE NEUROPSYCHIATRY (2019):13.
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