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Peripubertal stress of male, but not female rats increases morphine-induced conditioned place preference and locomotion in adulthood
Wang, Dong-Mei1,2; Zhang, Jian-Jun1,2; Huang, Yan-Bei1,2; Zhao, Yin-Zhu3; Sui, Nan1,2
First AuthorDong‐Mei Wang
2019-09-01
Source PublicationDEVELOPMENTAL PSYCHOBIOLOGY
Correspondent Emailsuin@psych.ac.cn
ISSN0012-1630
Subtypearticle
Volume61Issue:6Pages:920-929
Contribution Rank1
Abstract

Animal studies demonstrate that peripubertal social stress markedly increases the risk for subsequent substance use in adulthood. However, whether non-social stress has a similar long-term impact is not clear, and whether male and female animals show different sensitivity to peripubertal non-social stress has not been examined. In the present study, we addressed these issues by introducing two non-social stressors (elevated platform and predator odor 2,5-Dihydro-2,4,5-trimethylthiazoline) to male and female Wistar rats during adolescence (postnatal days 28-30, 34, 36, 40, and 42), then tested reward-related behaviors during adulthood, including morphine-induced conditioned place preference (CPP, 1 mg/kg morphine or 5 mg/kg morphine) and hyperlocomotor activity (5 mg/kg morphine). We found that adult male rats, but not females who were exposed to peripubertal non-social stressors showed enhanced morphine-induced CPP. Moreover, morphine-induced increase in locomotor activity was also significantly increased in adult male rats, but not in females. These results indicate that peripubertal exposure to repeated non-social stress may enhance sensitivity to the rewarding effects of opioids in adulthood in a sex-dependent manner, with males being even more sensitive than females in this regard.

Keywordconditioned place preference locomotor activity morphine Peripubertal stress sex difference
DOI10.1002/dev.21839
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program Grant ; Project for Young Scientists Fund, Institute of Psychology, CAS ; National Natural Science Foundation
Funding ProjectNational Basic Research Program Grant[2015CB553501] ; Project for Young Scientists Fund, Institute of Psychology, CAS[Y0CX081S01] ; National Natural Science Foundation[31300848] ; National Natural Science Foundation[31400880]
WOS Research AreaDevelopmental Biology ; Psychology
WOS SubjectDevelopmental Biology ; Psychology
WOS IDWOS:000485044700009
PublisherWILEY
WOS KeywordSOCIAL DEFEAT ; JUVENILE STRESS ; SEX-DIFFERENCES ; UNCONDITIONED FEAR ; PREFRONTAL CORTEX ; APPARATUS BIAS ; TRAUMA HISTORY ; PREDATOR ODOR ; ADOLESCENT ; EXPRESSION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29806
Collection中国科学院心理健康重点实验室
Corresponding AuthorSui, Nan
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Wang, Dong-Mei,Zhang, Jian-Jun,Huang, Yan-Bei,et al. Peripubertal stress of male, but not female rats increases morphine-induced conditioned place preference and locomotion in adulthood[J]. DEVELOPMENTAL PSYCHOBIOLOGY,2019,61(6):920-929.
APA Wang, Dong-Mei,Zhang, Jian-Jun,Huang, Yan-Bei,Zhao, Yin-Zhu,&Sui, Nan.(2019).Peripubertal stress of male, but not female rats increases morphine-induced conditioned place preference and locomotion in adulthood.DEVELOPMENTAL PSYCHOBIOLOGY,61(6),920-929.
MLA Wang, Dong-Mei,et al."Peripubertal stress of male, but not female rats increases morphine-induced conditioned place preference and locomotion in adulthood".DEVELOPMENTAL PSYCHOBIOLOGY 61.6(2019):920-929.
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