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Electroacupuncture Modulates Resting-State Functional Connectivity in the Default Mode Network for Healthy Older Adults
Fan, Dong-qiong1,2; Zhao, Hai-chao2; Sheng, Jing1; Liu, Yun-rui1; Yu, Jing1,3
First AuthorFan, Dong-qiong
Correspondent Emailhelen12@swu.edu.cn
Contribution Rank3
Abstract

Aging involves cognitive decline and prominent alterations in brain activity. Electroacupuncture (EA), a traditional Chinese medicine approach, is demonstrated to be effective in improving cognitive function of older adults. However, the specific neural mechanism underlying this modulation effect remains unclear. In this study, we used functional magnetic resonance imaging (fMRI) to investigate whether EA could improve cognitive performance of community-dwelling older adults and whether these potential improvements are associated with the EA-induced brain functional connectivity alterations. Thirty healthy older adults were recruited and randomly assigned to the EA group and the control group. Behaviorally, we observed an EA-induced improvement in cognitive performance of older adults in the Montreal Cognitive Assessment. On a neural perspective, the EA intervention significantly increased the functional connectivity within the default mode network. Moreover, we found a positive association between the improvement in delayed memory performance and the alterations in the ventral medial prefrontal cortex-hippocampal formation connectivity in the EA group. This study extends previous findings by showing that healthy older adults exhibit neural plasticity manifested as increased functional connectivity after EA sessions, which could induce therapeutic effects in the treatment of neurodegenerative diseases.

Keywordelectroacupuncture older adults resting state functional connectivity default mode network
2019-08-13
Language英语
DOI10.1177/0891988719868304
Source PublicationJOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
ISSN0891-9887
Pages8
SubtypeArticle
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31300856] ; Ministry of Education of Humanities and Social Science project[17YJA190015] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K02] ; Fundamental Research Funds for the Central Universities[SWU1709221]
PublisherSAGE PUBLICATIONS INC
WOS KeywordMILD COGNITIVE IMPAIRMENT ; NONINVASIVE BRAIN-STIMULATION ; BRIEF SCREENING TOOL ; ALZHEIMERS-DISEASE ; ACUPUNCTURE STIMULATION ; METABOLISM ; VERSION
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology ; Psychiatry
WOS SubjectGeriatrics & Gerontology ; Clinical Neurology ; Psychiatry
WOS IDWOS:000483173400001
Funding OrganizationNational Natural Science Foundation of China ; Ministry of Education of Humanities and Social Science project ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Fundamental Research Funds for the Central Universities
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29821
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Jing
Affiliation1.Southwest Univ, Fac Psychol, Tiansheng Rd, Chongqing 400715, Peoples R China
2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Fan, Dong-qiong,Zhao, Hai-chao,Sheng, Jing,et al. Electroacupuncture Modulates Resting-State Functional Connectivity in the Default Mode Network for Healthy Older Adults[J]. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,2019:8.
APA Fan, Dong-qiong,Zhao, Hai-chao,Sheng, Jing,Liu, Yun-rui,&Yu, Jing.(2019).Electroacupuncture Modulates Resting-State Functional Connectivity in the Default Mode Network for Healthy Older Adults.JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,8.
MLA Fan, Dong-qiong,et al."Electroacupuncture Modulates Resting-State Functional Connectivity in the Default Mode Network for Healthy Older Adults".JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2019):8.
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