Anterior cingulate cortex modulates the affective-motivative dimension of hyperosmolality-induced thirst

doi:10.1113/JP278301

	Anterior cingulate cortex modulates the affective-motivative dimension of hyperosmolality-induced thirst
	Ma, Longyu 1,2; Zhang, Yuqi 1,2; Yue, Lupeng 3,4; Zhang, Xueying 5; Cui, Shuang 1,2; Liu, Feng-Yu 1,2; Wan, You 1,2,6; Yi, Ming 1,2,6
通讯作者	Wan, You(ywan@hsc.pku.edu.cn) ; Yi, Ming(mingyi@hsc.pku.edu.cn)
摘要	Neuroimaging studies have shown that the anterior cingulate cortex (ACC) is consistently activated by thirst and may underlie the affective motivation of drinking behaviour demanded by thirst. But direct evidence for this hypothesis is lacking. The present study evaluated potential correlations between ACC neuronal activity and drinking behaviour in rats injected with different concentrations of saline. We observed an increased number of c-Fos-positive neurons in the ACC after injection of hypertonic saline, indicating strong ACC neuronal activation under hyperosmotic thirst. Increased firing rates of putative ACC pyramidal neurons preceded drinking behaviour and positively correlated with both the total duration of drinking and the total amount of water consumed. Chemogenetic inhibition of ACC pyramidal neurons changed drinking behaviour from an explosive and short-lasting pattern to a gradual but more persistent pattern, without affecting either the total duration of drinking or the total amount of water consumed. Together, these findings support a role of the ACC in modulating the affective-motivative dimension of hyperosmolality-induced thirst.
关键词	anterior cingulate cortex drinking behaviour electrophysiology thirst
	2019-09-01
语种	英语
DOI	10.1113/JP278301
发表期刊	JOURNAL OF PHYSIOLOGY-LONDON
ISSN	0022-3751
卷号	597 期号:18 页码:4851-4860
收录类别	SCI
出版者	WILEY
WOS关键词	WATER ; NEURONS ; FLUID ; STIMULATION ; RESPONSES ; DRINKING ; NUCLEUS ; BRAIN ; PAIN
WOS研究方向	Neurosciences & Neurology ; Physiology
WOS类目	Neurosciences ; Physiology
WOS记录号	WOS:000485981300015
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/29843
专题	中国科学院心理健康重点实验室
通讯作者	Wan, You; Yi, Ming
作者单位	1.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100083, Peoples R China 2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China 5.Capital Med Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100069, Peoples R China 6.Peking Univ, Key Lab Neurosci, Minist Educ, Natl Hlth Commiss, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Ma, Longyu,Zhang, Yuqi,Yue, Lupeng,et al. Anterior cingulate cortex modulates the affective-motivative dimension of hyperosmolality-induced thirst[J]. JOURNAL OF PHYSIOLOGY-LONDON,2019,597(18):4851-4860.
APA	Ma, Longyu.,Zhang, Yuqi.,Yue, Lupeng.,Zhang, Xueying.,Cui, Shuang.,...&Yi, Ming.(2019).Anterior cingulate cortex modulates the affective-motivative dimension of hyperosmolality-induced thirst.JOURNAL OF PHYSIOLOGY-LONDON,597(18),4851-4860.
MLA	Ma, Longyu,et al."Anterior cingulate cortex modulates the affective-motivative dimension of hyperosmolality-induced thirst".JOURNAL OF PHYSIOLOGY-LONDON 597.18(2019):4851-4860.

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