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Early life stress predicts cortisol response to psychosocial stress in healthy young adults
Zhang, Huihui1,2; Yao, Zhuxi1,3; Lin, Li1,2; Sun, Xiaofang1,4; Shi, Xia1; Zhang, Liang1,2
First AuthorZhang, Huihui
Correspondent Emailzhangl@psych.ac.cn
2019-09-01
Source PublicationPSYCH JOURNAL
ISSN2046-0252
Subtypearticle
Volume8Issue:3Pages:353-362
QuartileQ3
Contribution Rank1
Abstract

Repeated exposure to stress during early life has a lifetime impact on physical and psychological functions. Our study investigated the long-term effects of early life stress (ELS; measured retrospectively) on the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system functions under psychosocial stress among healthy adults. Fifty healthy volunteers (33 male, 17 female, mean age 22.6 +/- 1.8 years) underwent a standardized psychosocial stress protocol (the Trier Social Stress Test), with the collection of salivary cortisol, heart rates, and positive and negative affect. The results showed increases in cortisol, heart rate, and negative affect after the stress inducement. More importantly, a significant negative correlation was found between the severity of ELS and the increase of cortisol to the stress. The severity of stress in one's early life predicted his/her cortisol reactivity to the stress in adulthood. Neither the heart rate reactivity nor the affective reactivity shows significant association with ELS. The blunted cortisol reactivity reflects the alteration of the HPA axis, which may confer the risk for certain stress-related disorders.

Keywordcortisol early life stress hypothalamic-pituitary-adrenal axis psychosocial stress
DOI10.1002/pchj.278
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Plan ; National Science Foundation of China
Funding ProjectNational Key Research and Development Plan[2018YFC0831101] ; National Science Foundation of China[U1736220]
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000483561000008
PublisherWILEY
WOS KeywordADVERSE CHILDHOOD EXPERIENCES ; AXIS REACTIVITY ; SOCIAL STRESS ; TRAUMA ; WOMEN ; PATHOPHYSIOLOGY ; ASSOCIATIONS ; POPULATION ; VALIDATION ; DISORDERS
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29846
Collection中国科学院行为科学重点实验室
Corresponding AuthorZhang, Liang
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China
4.Tsinghua Univ, Dept Ind Engn, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Behavioral Science, CAS
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Zhang, Huihui,Yao, Zhuxi,Lin, Li,et al. Early life stress predicts cortisol response to psychosocial stress in healthy young adults[J]. PSYCH JOURNAL,2019,8(3):353-362.
APA Zhang, Huihui,Yao, Zhuxi,Lin, Li,Sun, Xiaofang,Shi, Xia,&Zhang, Liang.(2019).Early life stress predicts cortisol response to psychosocial stress in healthy young adults.PSYCH JOURNAL,8(3),353-362.
MLA Zhang, Huihui,et al."Early life stress predicts cortisol response to psychosocial stress in healthy young adults".PSYCH JOURNAL 8.3(2019):353-362.
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