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Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach
Zhu, Ruida2,3,5; Liu, Chao2,3,4,5; Li, Ting11; Xu, Zhenhua2,3,4,5; Fung, Bowen7,8; Feng, Chunliang1; Wu, Haiyan7,8,9; Luo, Yi10; Wang, Li6
2019-10-01
Source PublicationPSYCHONEUROENDOCRINOLOGY
Correspondent Emailchunliang.feng@gmail.com (c. feng) ; haiyanwu@caltech.edu (h. wu) ; luoyi0704@gmail.com (y. luo) ; mykd3210@gmail.com (l. wang)
ISSN0306-4530
Subtypearticle
Volume108Pages:172-181
Contribution Rank7
Abstract

Aggression is an important behaviour that concerns individual survival and large-scale social stability. It comprises a variety of psychological subcomponents and is modulated by different biological factors. Two factors in particular, gender and oxytocin, appear to play a robust role in aggressive behaviour. However, whether these two factors interact to impact aggressive behaviour is not currently known. The current study investigated the modulating effect of gender on the relationship between oxytocin and aggression and characterized its underlying mechanisms by combining behavioural economic, pharmacological, and computational approaches. Specifically, we employed a double-blind, randomized, placebo-controlled, between-subjects design, in which one hundred participants (50 men and 50 women) completed a norm-training version of the multi-round one-shot ultimatum game (UG) after intranasal oxytocin or placebo administration. Rejection rates in the UG were adopted as an indicator of reactive aggression. The results indicated that oxytocin compared with placebo administration decreased aggression among men but not among women. Further analyses suggested that this decrease in aggression was a result of changes in men's sensitivity to provocation and positive affect, rather than norm adaptation rates or concerns about the cost of aggression. These findings highlight the role of gender in the relationship between oxytocin and reactive aggression and reveal its underlying psychological and computational mechanisms.

KeywordOxytocin Reactive aggression Gender Sensitivity to provocation Positive affect
DOI10.1016/j.psyneuen.2019.06.016
Indexed BySCI
Language英语
Funding OrganizationNational Postdoctoral Program for Innovative Talents ; China Postdoctoral Science Foundation ; CAS Key Laboratory of Behavioral Science, Institute of Psychology ; National Natural Science Foundation of China ; China Scholarship Council
Funding ProjectNational Postdoctoral Program for Innovative Talents[BX201600019] ; China Postdoctoral Science Foundation[2017M610055] ; CAS Key Laboratory of Behavioral Science, Institute of Psychology[Y5CX052003] ; National Natural Science Foundation of China[31400963] ; National Natural Science Foundation of China[U1736125] ; China Scholarship Council[201706040120]
WOS Research AreaEndocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
WOS SubjectEndocrinology & Metabolism ; Neurosciences ; Psychiatry
WOS IDWOS:000484870800022
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordNEGATIVE AFFECT ; SEX-DIFFERENCES ; NEURAL MECHANISMS ; VASOPRESSIN ; RESPONSES ; AMYGDALA ; STRESS ; INDIVIDUALS ; PROVOCATION ; REJECTIONS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29861
Collection中国科学院行为科学重点实验室
Corresponding AuthorFeng, Chunliang; Wu, Haiyan; Luo, Yi; Wang, Li
Affiliation1.South China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat, Guangdong Prov Key Lab Mental Hlth & Cognit Sci, Guangzhou, Guangdong, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
3.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China
4.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing, Peoples R China
5.Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connecto, Beijing, Peoples R China
6.Beijing Normal Univ, Collaborat Innovat Ctr Assessment Basic Educ Qual, Beijing, Peoples R China
7.CALTECH, Div Human & Social Sci, Pasadena, CA 91125 USA
8.CALTECH, Computat & Neural Syst Program, Pasadena, CA 91125 USA
9.Univ Chinese Acad Sci, Dept Psychol, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
10.Virginia Tech, Fralin Biomed Res Inst VTC, Roanoke, VA 24016 USA
11.South China Normal Univ, IBRR, Guangzhou, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Ruida,Liu, Chao,Li, Ting,et al. Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach[J]. PSYCHONEUROENDOCRINOLOGY,2019,108:172-181.
APA Zhu, Ruida.,Liu, Chao.,Li, Ting.,Xu, Zhenhua.,Fung, Bowen.,...&Wang, Li.(2019).Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach.PSYCHONEUROENDOCRINOLOGY,108,172-181.
MLA Zhu, Ruida,et al."Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach".PSYCHONEUROENDOCRINOLOGY 108(2019):172-181.
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