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Functional fractionation of default mode network in first episode schizophrenia
Fan, Fengmei1,2,3; Tan, Yunlong1; Wang, Zhiren1; Yang, Fude1; Fan, Hongzhen1; Xiang, Hong4; Guo, Hua5; Hong, L. Elliot6; Tan, Shuping1; Zuo, Xi-Nian7,8,9,10,11,12
First AuthorFan, Fengmei
2019-08-01
Source PublicationSCHIZOPHRENIA RESEARCH
Correspondent Emailshupingtan@126.com (s. tan) ; zuoxn@psych.ac.cn (x.-n. zuo).
ISSN0920-9964
Subtypearticle
Volume210Pages:115-121
Contribution Rank6
Abstract

A disruption in the connectivity between brain regions may underlie the core pathology in schizophrenia. One of the most consistent observations in human functional imaging is a network of brain regions referred to as the default network (DMN) that contains core subsystem, the dorsomedial prefrontal cortex (dMPFC) subsystem and the medial temporal lobe (MTL) subsystem, with differential contributions. The goal of this study was to examine abnormalities of differentDMN subsystems in first episode schizophrenia and associations between these abnormalities and individual psychopathology. We recruited 203 patients and 131 healthy controls. A seed-based resting-state functional connectivity (RSFC) analysis on the 2D surface was conducted. Individual DMN functional connectivity matrices were then obtained by calculating spatial correlations between pairs of RSFC maps, characterizing the functional fractionation of the DMN. Patients showed patterns similar to controls but markedly reduced strength of DMN fractionation, with the degree centrality of the MTL subsystem significantly reduced, including the posterior inferior parietal lobule (pIPL), parahippocampal cortex (PHC) and lateral temporal cortex (LTC). Patients also exhibited hypo-connectivity within the MTL subsystem and between the MTL and dMPFC subsystems. Clinical symptoms were negatively correlated with degree centrality of LTC, pIPL and PHC in patients. Hyper-fractionation of different DMN components implied that communication and coordination throughout the dissociated components of the DMN are functionally over-segregated in schizophrenia. The associations between the hyper-fractionation with clinical symptoms suggest a role of the high fractionation in the DMN in the abnormal neuropathology observed in schizophrenia. (C) 2019 Published by Elsevier B.V.

KeywordSchizophrenia Default network Functional fractionation Graph Resting state Functional MRI
DOI10.1016/j.schres.2019.05.038
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Institutes of Health ; Beijing Municipal Administration of Hospitals' Youth Programme
Funding ProjectNational Natural Science Foundation of China[81401115] ; National Natural Science Foundation of China[81761128021] ; National Natural Science Foundation of China[31671145] ; National Institutes of Health[R01MH112180] ; Beijing Municipal Administration of Hospitals' Youth Programme[QML20172001]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000479125500018
PublisherELSEVIER
WOS KeywordTASK-INDUCED DEACTIVATION ; SURFACE-BASED ANALYSIS ; RESTING-STATE ; AUTOBIOGRAPHICAL MEMORY ; PREFRONTAL CORTEX ; PSYCHOTIC SYMPTOMS ; SELF-DISORDERS ; HEAD MOTION ; BOLD SIGNAL ; ICA-AROMA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29900
Collection中国科学院行为科学重点实验室
Corresponding AuthorTan, Shuping; Zuo, Xi-Nian
Affiliation1.Peking Univ, Huilongguan Clin Med Chool, Beijing Huilongguan Hosp, Beijing 100096, Peoples R China
2.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, McGovern Inst Brain Res, Int Data Grp, Beijing 100875, Peoples R China
4.Chongqing Three Gorges Cent Hosp, Chongqing 404000, Peoples R China
5.Zhumadian Psychiat Hosp, Zhumadian, Henan, Peoples R China
6.Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA
7.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
8.Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
9.Inst Psychol, Res Ctr Lifespan Dev Mind & Brain, Beijing, Peoples R China
10.Inst Psychol, Lifespan Connect & Behav Team, Beijing, Peoples R China
11.Guangxi Teachers Educ Univ, Key Lab Brain & Educ Sci, Nanning, Guangxi, Peoples R China
12.Guangxi Teachers Educ Univ, Ctr Longev Res, Nanning, Guangxi, Peoples R China
Recommended Citation
GB/T 7714
Fan, Fengmei,Tan, Yunlong,Wang, Zhiren,et al. Functional fractionation of default mode network in first episode schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2019,210:115-121.
APA Fan, Fengmei.,Tan, Yunlong.,Wang, Zhiren.,Yang, Fude.,Fan, Hongzhen.,...&Zuo, Xi-Nian.(2019).Functional fractionation of default mode network in first episode schizophrenia.SCHIZOPHRENIA RESEARCH,210,115-121.
MLA Fan, Fengmei,et al."Functional fractionation of default mode network in first episode schizophrenia".SCHIZOPHRENIA RESEARCH 210(2019):115-121.
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