Institutional Repository of Key Laboratory of Mental Health, CAS
D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy | |
Yu, Lexiang2; Chen, Yao1; Xu, Yong5; He, Tao1; Wei, Yan2,4; He, Rongqiao1,2,3 | |
第一作者 | Lexiang Yu |
通讯作者邮箱 | yanwei@ibp.ac.cn ; rongqiaohe@163.com |
心理所单位排序 | 2 |
摘要 | Although many mechanisms have been proposed for diabetic encephalopathy in type 2 diabetes mellitus (T2DM), the risk factors for cognitive impairment in type 1 diabetes mellitus (T1DM) are less clear. Here, we show that streptozotocin (STZ)-induced T1DM rats showed cognitive impairment in both Y maze and Morris water maze assays, accompanied with D-ribose was significantly increased in blood and urine, in addition to D-glucose. Furthermore, advanced glycation end products (AGE), Tau hyperphosphorylation and neuronal death in the hippocampal CA4/DG region were detected in T1DM rats. The expression and activity of transketolase (TKT), an important enzyme in the pentose shunt, were decreased in the brain, indicating that TKT may be involved in D-ribose metabolism in T1DM. Support for these change was demonstrated by the activation of TKT with benfotiamine (BTMP) treatment. Decreased D-ribose levels but not D-glucose levels; markedly reduced AGE accumulation, Tau hyperphosphorylation, and neuronal death; and improved cognitive ability in T1DM rats were shown after BTMP administration. In clinical investigation, T1DM patients had high D-ribose levels in both urine and serum. Our work suggests that D-ribose is involved in the cognitive impairment in T1DM and may provide a potentially novel target for treating diabetic encephalopathy. |
关键词 | D-ribose benfotiamine (BTMP) cognitive impairment type 1 diabetic encephalopathy type 1 diabetes mellitus (T1DM) diabetic encephalopathy |
2019-07-31 | |
语种 | 英语 |
DOI | 10.18632/aging.102089 |
发表期刊 | AGING-US |
ISSN | 1945-4589 |
卷号 | 11期号:14页码:4943-4969 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | Natural Scientific Foundation of China NSFC[31670805] ; Natural Scientific Foundation of China NSFC[81573763] ; National Key Research and Development Program of China[2016YFC1305900] ; National Key Research and Development Program of China[2016YFC1306300] ; Beijing Municipal Science and Technology Project[Z161100000217141] ; Beijing Municipal Science and Technology Project[Z161100000216137] ; Youth Innovation Promotion Association CAS[2017132] |
出版者 | IMPACT JOURNALS LLC |
WOS关键词 | PENTOSE-PHOSPHATE PATHWAY ; GLYCATION END-PRODUCTS ; OXIDATIVE STRESS ; COGNITIVE IMPAIRMENT ; DIABETES-MELLITUS ; VITAMIN-B1 ANALOG ; ALZHEIMER-DISEASE ; CELL-DEATH ; BENFOTIAMINE ; MEMORY |
WOS研究方向 | Cell Biology ; Geriatrics & Gerontology |
WOS类目 | Cell Biology ; Geriatrics & Gerontology |
WOS记录号 | WOS:000479140500015 |
资助机构 | Natural Scientific Foundation of China NSFC ; National Key Research and Development Program of China ; Beijing Municipal Science and Technology Project ; Youth Innovation Promotion Association CAS |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/29912 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wei, Yan; He, Rongqiao |
作者单位 | 1.Southwest Med Univ, Sch Basic Med Sci, Luzhou 646000, Sichuan, Peoples R China 2.Univ Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 3.Capital Med Univ, Ctr Brain Disorders Res, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Southwest Med Univ, Affiliated Hosp, Luzhou 646000, Peoples R China |
第一作者单位 | 脑与认知科学国家重点实验室 |
通讯作者单位 | 脑与认知科学国家重点实验室; 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Yu, Lexiang,Chen, Yao,Xu, Yong,et al. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy[J]. AGING-US,2019,11(14):4943-4969. |
APA | Yu, Lexiang,Chen, Yao,Xu, Yong,He, Tao,Wei, Yan,&He, Rongqiao.(2019).D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy.AGING-US,11(14),4943-4969. |
MLA | Yu, Lexiang,et al."D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy".AGING-US 11.14(2019):4943-4969. |
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