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D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy
Yu, Lexiang2; Chen, Yao1; Xu, Yong5; He, Tao1; Wei, Yan2,4; He, Rongqiao1,2,3
第一作者Lexiang Yu
通讯作者邮箱yanwei@ibp.ac.cn ; rongqiaohe@163.com
心理所单位排序2
摘要

Although many mechanisms have been proposed for diabetic encephalopathy in type 2 diabetes mellitus (T2DM), the risk factors for cognitive impairment in type 1 diabetes mellitus (T1DM) are less clear. Here, we show that streptozotocin (STZ)-induced T1DM rats showed cognitive impairment in both Y maze and Morris water maze assays, accompanied with D-ribose was significantly increased in blood and urine, in addition to D-glucose. Furthermore, advanced glycation end products (AGE), Tau hyperphosphorylation and neuronal death in the hippocampal CA4/DG region were detected in T1DM rats. The expression and activity of transketolase (TKT), an important enzyme in the pentose shunt, were decreased in the brain, indicating that TKT may be involved in D-ribose metabolism in T1DM. Support for these change was demonstrated by the activation of TKT with benfotiamine (BTMP) treatment. Decreased D-ribose levels but not D-glucose levels; markedly reduced AGE accumulation, Tau hyperphosphorylation, and neuronal death; and improved cognitive ability in T1DM rats were shown after BTMP administration. In clinical investigation, T1DM patients had high D-ribose levels in both urine and serum. Our work suggests that D-ribose is involved in the cognitive impairment in T1DM and may provide a potentially novel target for treating diabetic encephalopathy.

关键词D-ribose benfotiamine (BTMP) cognitive impairment type 1 diabetic encephalopathy type 1 diabetes mellitus (T1DM) diabetic encephalopathy
2019-07-31
语种英语
DOI10.18632/aging.102089
发表期刊AGING-US
ISSN1945-4589
卷号11期号:14页码:4943-4969
期刊论文类型article
收录类别SCI
资助项目Natural Scientific Foundation of China NSFC[31670805] ; Natural Scientific Foundation of China NSFC[81573763] ; National Key Research and Development Program of China[2016YFC1305900] ; National Key Research and Development Program of China[2016YFC1306300] ; Beijing Municipal Science and Technology Project[Z161100000217141] ; Beijing Municipal Science and Technology Project[Z161100000216137] ; Youth Innovation Promotion Association CAS[2017132]
出版者IMPACT JOURNALS LLC
WOS关键词PENTOSE-PHOSPHATE PATHWAY ; GLYCATION END-PRODUCTS ; OXIDATIVE STRESS ; COGNITIVE IMPAIRMENT ; DIABETES-MELLITUS ; VITAMIN-B1 ANALOG ; ALZHEIMER-DISEASE ; CELL-DEATH ; BENFOTIAMINE ; MEMORY
WOS研究方向Cell Biology ; Geriatrics & Gerontology
WOS类目Cell Biology ; Geriatrics & Gerontology
WOS记录号WOS:000479140500015
资助机构Natural Scientific Foundation of China NSFC ; National Key Research and Development Program of China ; Beijing Municipal Science and Technology Project ; Youth Innovation Promotion Association CAS
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/29912
专题中国科学院心理健康重点实验室
通讯作者Wei, Yan; He, Rongqiao
作者单位1.Southwest Med Univ, Sch Basic Med Sci, Luzhou 646000, Sichuan, Peoples R China
2.Univ Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Capital Med Univ, Ctr Brain Disorders Res, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Southwest Med Univ, Affiliated Hosp, Luzhou 646000, Peoples R China
第一作者单位脑与认知科学国家重点实验室
通讯作者单位脑与认知科学国家重点实验室;  中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Yu, Lexiang,Chen, Yao,Xu, Yong,et al. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy[J]. AGING-US,2019,11(14):4943-4969.
APA Yu, Lexiang,Chen, Yao,Xu, Yong,He, Tao,Wei, Yan,&He, Rongqiao.(2019).D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy.AGING-US,11(14),4943-4969.
MLA Yu, Lexiang,et al."D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy".AGING-US 11.14(2019):4943-4969.
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