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D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy
Yu, Lexiang2; Chen, Yao1; Xu, Yong5; He, Tao1; Wei, Yan2,4; He, Rongqiao1,2,3
First AuthorLexiang Yu
2019-07-31
Source PublicationAGING-US
Correspondent Emailyanwei@ibp.ac.cn ; rongqiaohe@163.com
ISSN1945-4589
Subtypearticle
Volume11Issue:14Pages:4943-4969
Contribution Rank2
Abstract

Although many mechanisms have been proposed for diabetic encephalopathy in type 2 diabetes mellitus (T2DM), the risk factors for cognitive impairment in type 1 diabetes mellitus (T1DM) are less clear. Here, we show that streptozotocin (STZ)-induced T1DM rats showed cognitive impairment in both Y maze and Morris water maze assays, accompanied with D-ribose was significantly increased in blood and urine, in addition to D-glucose. Furthermore, advanced glycation end products (AGE), Tau hyperphosphorylation and neuronal death in the hippocampal CA4/DG region were detected in T1DM rats. The expression and activity of transketolase (TKT), an important enzyme in the pentose shunt, were decreased in the brain, indicating that TKT may be involved in D-ribose metabolism in T1DM. Support for these change was demonstrated by the activation of TKT with benfotiamine (BTMP) treatment. Decreased D-ribose levels but not D-glucose levels; markedly reduced AGE accumulation, Tau hyperphosphorylation, and neuronal death; and improved cognitive ability in T1DM rats were shown after BTMP administration. In clinical investigation, T1DM patients had high D-ribose levels in both urine and serum. Our work suggests that D-ribose is involved in the cognitive impairment in T1DM and may provide a potentially novel target for treating diabetic encephalopathy.

KeywordD-ribose benfotiamine (BTMP) cognitive impairment type 1 diabetic encephalopathy type 1 diabetes mellitus (T1DM) diabetic encephalopathy
DOI10.18632/aging.102089
Indexed BySCI
Language英语
Funding OrganizationNatural Scientific Foundation of China NSFC ; National Key Research and Development Program of China ; Beijing Municipal Science and Technology Project ; Youth Innovation Promotion Association CAS
Funding ProjectNatural Scientific Foundation of China NSFC[31670805] ; Natural Scientific Foundation of China NSFC[81573763] ; National Key Research and Development Program of China[2016YFC1305900] ; National Key Research and Development Program of China[2016YFC1306300] ; Beijing Municipal Science and Technology Project[Z161100000217141] ; Beijing Municipal Science and Technology Project[Z161100000216137] ; Youth Innovation Promotion Association CAS[2017132]
WOS Research AreaCell Biology ; Geriatrics & Gerontology
WOS SubjectCell Biology ; Geriatrics & Gerontology
WOS IDWOS:000479140500015
PublisherIMPACT JOURNALS LLC
WOS KeywordPENTOSE-PHOSPHATE PATHWAY ; GLYCATION END-PRODUCTS ; OXIDATIVE STRESS ; COGNITIVE IMPAIRMENT ; DIABETES-MELLITUS ; VITAMIN-B1 ANALOG ; ALZHEIMER-DISEASE ; CELL-DEATH ; BENFOTIAMINE ; MEMORY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29912
Collection中国科学院心理健康重点实验室
Corresponding AuthorWei, Yan; He, Rongqiao
Affiliation1.Southwest Med Univ, Sch Basic Med Sci, Luzhou 646000, Sichuan, Peoples R China
2.Univ Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Capital Med Univ, Ctr Brain Disorders Res, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Southwest Med Univ, Affiliated Hosp, Luzhou 646000, Peoples R China
Recommended Citation
GB/T 7714
Yu, Lexiang,Chen, Yao,Xu, Yong,et al. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy[J]. AGING-US,2019,11(14):4943-4969.
APA Yu, Lexiang,Chen, Yao,Xu, Yong,He, Tao,Wei, Yan,&He, Rongqiao.(2019).D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy.AGING-US,11(14),4943-4969.
MLA Yu, Lexiang,et al."D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy".AGING-US 11.14(2019):4943-4969.
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