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Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory
Deng, Xiaofei1,2; Gu, Lijia1,2; Sui, Nan1,2; Guo, Jianyou1,2; Liang, Jing1,2
First AuthorDeng, Xiaofei
2019-08-13
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Correspondent Emailguojy@psych.ac.cn ; liangj@psych.ac.cn.
ISSN0027-8424
Subtypearticle
Volume116Issue:33Pages:16583-16592
Contribution Rank1
Abstract

The ability to identify strange conspecifics in societies is supported by social memory, which is vital for gregarious animals and humans. The function of hippocampal principal neurons in social memory has been extensively investigated; however, the nonprincipal neuronal mechanism underlying social memory remains unclear. Here, we first observed parallel changes in the ability for social recognition and the number of parvalbumin interneurons (PVIs) in the ventral CA1 (vCA1) after social isolation. Then, using tetanus toxin-mediated neuronal lesion and optogenetic stimulation approaches, we revealed that vCA1-PVIs specifically engaged in the retrieval stage of social memory. Finally, through the in vivo Ca2+ imaging technique, we demonstrated that vCA1-PVIs exhibited higher activities when subjected mice approached a novel mouse than to a familiar one. These results highlight the crucial role of vCA1-PVIs for distinguishing novel conspecifics from other individuals and contribute to our understanding of the neuropathology of mental diseases with social memory deficits.

Keywordsocial memory hippocampus interneurons parvalbumin
DOI10.1073/pnas.1819133116
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Key Basic Research Program of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Funding ProjectNational Natural Science Foundation of China[31571108] ; National Natural Science Foundation of China[31371038] ; Beijing Natural Science Foundation[5162023] ; National Key Basic Research Program of China[2015CB553501] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000481404300066
PublisherNATL ACAD SCIENCES
WOS KeywordIMMUNOREACTIVE NEURONS ; PROTEIN PARVALBUMIN ; GABAERGIC NEURONS ; OXIDATIVE STRESS ; RAT HIPPOCAMPUS ; CA2 REGION ; CELLS ; MICE ; CONSOLIDATION ; INVOLVEMENT
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29915
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuo, Jianyou; Liang, Jing
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Deng, Xiaofei,Gu, Lijia,Sui, Nan,et al. Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(33):16583-16592.
APA Deng, Xiaofei,Gu, Lijia,Sui, Nan,Guo, Jianyou,&Liang, Jing.(2019).Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(33),16583-16592.
MLA Deng, Xiaofei,et al."Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.33(2019):16583-16592.
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