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Hyperconnectivity in perisylvian language pathways in schizophrenia with auditory verbal hallucinations: A multi-site diffusion MRI study
Xie, Sangma1; Liu, Bing2,3,4,5; Wang, Jiaojian6; Zhou, Yuan7,8; Cui, Yue2,3,4; Song, Ming2,3,4; Chen, Yunchun9; Li, Peng10,11; Lui, Lin10,11; Lv, Luxian12,13; Wang, Huaning9; Yan, Hao10,11; Yan, Jun10,11; Zhang, Hongxing12,14; Zhang, Dai10,11,15; Jiang, Tianzi2,3,4,5,6
First AuthorXie, Sangma
2019-08-01
Source PublicationSCHIZOPHRENIA RESEARCH
Correspondent Emailjiangtz@nlpr.ia.ac.cn (t. jiang)
ISSN0920-9964
Subtypearticle
Volume210Pages:262-269
Contribution Rank7
Abstract

Auditory verbal hallucinations (AVH) are one of the cardinal symptoms of schizophrenia, and are proposed to be associatedwith altered integrity of the left perisylvian language pathways. There is considerable heterogeneity in the pattern of white matter abnormalities across previous studies. We investigated the white matter integrity of the perisylvian language pathways in schizophrenia patientswith AVH based on a relatively large sample dataset fromfour different sites. 113 schizophrenia patientswith AVH, 96 patientswithout AVH(nAVH), and 269 healthy controls (HC) underwent diffusion-weighted imaging. Between-group comparisonswere performed on the fractional anisotropy (FA) values of the anterior, posterior, and long segment fasciculi within the perisylvian language network. Analysis of covariance among the 3 groups revealed the long segment of the left perisylvian language pathways was significantly different in FA value. Post hoc analysis showed that compared with the HC group, the AVH group had significantly higher FA measurements in the left long segment. The nAVH group showed intermediate FA values for this segment compared to the AVH and HC group but did not differ significantly from either group. Furthermore, the prospective meta-analyses also revealed that FA value of the left long segment was significantly higher in the AVH group compared to the HC group. Our findings suggest the hyperconnectivity pattern of the left perisylvian language pathways in the presence of AVH in schizophrenia and support the self-monitoring of inner speech model. (C) 2018 Elsevier B.V. All rights reserved.

KeywordSchizophrenia Auditory verbal hallucination Perisylvian language pathways Diffusion tensor imaging Hyperconnectivity Multi-site
DOI10.1016/j.schres.2018.12.024
Indexed BySCI
Language英语
Funding OrganizationZhejiang Provincial Natural Science Foundation of China ; National Basic Research Program of China (973) ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Natural Science Foundation of China
Funding ProjectZhejiang Provincial Natural Science Foundation of China[LQ19F030012] ; National Basic Research Program of China (973)[2011CB707800] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02030300] ; Natural Science Foundation of China[91132301] ; Natural Science Foundation of China[91432302]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000479125500038
PublisherELSEVIER
WOS KeywordARCUATE FASCICULUS ; FUNCTIONAL CONNECTIVITY ; INTEGRITY ; NETWORKS ; STIMULATION ; PLASTICITY ; MOTION
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29918
Collection中国科学院行为科学重点实验室
Corresponding AuthorJiang, Tianzi
Affiliation1.Hangzhou Dianzi Univ, Coll Life Informat Sci & Instrument Engn, Hangzhou 310018, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Sichuan, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
8.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
9.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Shaanxi, Peoples R China
10.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
11.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
12.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
13.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
14.Xinxiang Med Univ, Dept Psychol, Xinxiang 453002, Henan, Peoples R China
15.Peking Univ, McGovem Inst Brain Res, PKU IDG, Ctr Life Sdences, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Xie, Sangma,Liu, Bing,Wang, Jiaojian,et al. Hyperconnectivity in perisylvian language pathways in schizophrenia with auditory verbal hallucinations: A multi-site diffusion MRI study[J]. SCHIZOPHRENIA RESEARCH,2019,210:262-269.
APA Xie, Sangma.,Liu, Bing.,Wang, Jiaojian.,Zhou, Yuan.,Cui, Yue.,...&Jiang, Tianzi.(2019).Hyperconnectivity in perisylvian language pathways in schizophrenia with auditory verbal hallucinations: A multi-site diffusion MRI study.SCHIZOPHRENIA RESEARCH,210,262-269.
MLA Xie, Sangma,et al."Hyperconnectivity in perisylvian language pathways in schizophrenia with auditory verbal hallucinations: A multi-site diffusion MRI study".SCHIZOPHRENIA RESEARCH 210(2019):262-269.
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