PSYCH OpenIR  > 中国科学院心理健康重点实验室
Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin
Liu, Yiqiong1,8; Sun, Yunong7; Zhao, Xiaoyan2; Kim, Ji-Young3; Luo, Lu4; Wang, Qian4; Meng, Xiaolu6; Li, Yonghui6; Sui, Nan6; Chen, Zhou-Feng3; Pan, Chuxiong2; Li, Liang4,5; Zhang, Yan1,8
2019-10-01
Source PublicationNEUROSCIENCE BULLETIN
Correspondent Emailliangli@pku.edu.cn ; yanzhang@pku.edu.cn
ISSN1673-7067
Subtypearticle
Volume35Issue:5Pages:841-852
Contribution Rank6
Abstract

Isolation rearing (IR) enhances aggressive behavior, and the central serotonin (5-hydroxytryptamine, 5-HT) system has been linked to IR-induced aggression. However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2(-/-) and Lmx1b(-/-), we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1b(-/-) mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1b(-/-) mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1b(-/-) mice. Our results link the serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions.

Keyword5-HT Aggression Social isolation Dopamine Lmx1b
DOI10.1007/s12264-019-00373-w
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Basic Research Development Program (973 Program) of China
Funding ProjectNational Natural Science Foundation of China[81425009] ; National Natural Science Foundation of China[31630028] ; National Natural Science Foundation of China[91632305] ; National Natural Science Foundation of China[30950030] ; National Natural Science Foundation of China[31170988] ; National Natural Science Foundation of China[81671044] ; National Basic Research Development Program (973 Program) of China[2009CB522002]
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000487192100006
PublisherSPRINGER
WOS KeywordWEANING SOCIAL-ISOLATION ; MEDIAL PREFRONTAL CORTEX ; ISOLATION-REARED RATS ; EARLY-LIFE STRESS ; PREPULSE INHIBITION ; TRYPTOPHAN DEPLETION ; STARTLE RESPONSE ; BRAIN-SEROTONIN ; IN-VIVO ; BEHAVIOR
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29989
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Liang; Zhang, Yan
Affiliation1.Peking Univ, Coll Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesiol, Beijing 100005, Peoples R China
3.Washington Univ, Sch Med, Dept Anesthesiol, Dept Psychiat,Dept Dev Biol,Ctr Study Itch, St Louis, MO 63110 USA
4.Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China
5.Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
7.Hendrix Coll, Conway, AR 72032 USA
8.PKU IDG McGovem Inst Brain Res, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yiqiong,Sun, Yunong,Zhao, Xiaoyan,et al. Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin[J]. NEUROSCIENCE BULLETIN,2019,35(5):841-852.
APA Liu, Yiqiong.,Sun, Yunong.,Zhao, Xiaoyan.,Kim, Ji-Young.,Luo, Lu.,...&Zhang, Yan.(2019).Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin.NEUROSCIENCE BULLETIN,35(5),841-852.
MLA Liu, Yiqiong,et al."Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin".NEUROSCIENCE BULLETIN 35.5(2019):841-852.
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