Institutional Repository of Key Laboratory of Mental Health, CAS
Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level | |
Zhang, Kunlin1,2; Fan, Zili3,4; Wang, Yufeng3,4; Faraone, Stephen, V5,6,7; Yan, Li3,4; Chang, Suhua1,2 | |
第一作者 | Kunlin Zhang |
通讯作者邮箱 | suhua chang changsh@psych.ac.cn ; li yang yangli_pkuimh@bjmu.edu.cn |
心理所单位排序 | 1 |
摘要 | Objectives: Investigation of the genetic basis of endophenotype and analysis the pathways with multiple genes of small effects might increase the understanding of the genetic basis of attention deficit hyperactivity disorder (ADHD). Here we aimed to explore the genetic basis of cognitive flexibility in ADHD at the single nucleotide polymorphism (SNP), gene and pathway levels. Methods: The trail-making test was used to test the cognitive flexibility of 788 ADHD patients. A genome-wide association analysis of cognitive flexibility was conducted for 644,166 SNPs. Results: The top SNP rs2049161 (P = 5.08e-7) involved gene DLGAP1 and the top gene CADPS2 in the gene-based analysis resulted in much literature evidence of associations with psychiatric disorders. Gene expression and network analysis showed their contribution to cognition function. The interval-enrichment analysis highlighted a potential contribution of 'adenylate cyclase activity' and ADCY2 to cognitive flexibility. Candidate pathway-based analysis for all SNPs found that glutamate system-, neurite outgrowth- and noradrenergic system-related pathways were significantly associated with cognitive flexibility (FDR <0.05), among which the neurite outgrowth pathway was also associated with ADHD symptoms. Conclusions: This study provides evidence for the genes and pathways associated with cognitive flexibility and facilitate the uncovering of the genetic basis of ADHD. |
关键词 | Attention deficit hyperactivity disorder cognitive flexibility trail-making test genome-wide association study genetics |
2019-07-03 | |
语种 | 英语 |
DOI | 10.1080/15622975.2017.1386324 |
发表期刊 | WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY |
ISSN | 1562-2975 |
卷号 | 20期号:6页码:476-485 |
期刊论文类型 | article |
收录类别 | SCI |
出版者 | TAYLOR & FRANCIS LTD |
WOS关键词 | CA2+-DEPENDENT ACTIVATOR PROTEIN ; GENOME-WIDE ASSOCIATION ; EXECUTIVE FUNCTION ; DEFICIT/HYPERACTIVITY DISORDER ; IDENTIFIES ASSOCIATION ; INDIVIDUAL-DIFFERENCES ; ENDOPHENOTYPE CONCEPT ; RESPONSE-INHIBITION ; ENRICHMENT ANALYSIS ; CANDIDATE GENES |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000486211100006 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/29995 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Yan, Li; Chang, Suhua |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 4.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China 5.SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA 6.SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA 7.Univ Bergen, KG Jebsen Ctr Res Neuropsychiat Disorders, Bergen, Norway |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Zhang, Kunlin,Fan, Zili,Wang, Yufeng,et al. Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level[J]. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,2019,20(6):476-485. |
APA | Zhang, Kunlin,Fan, Zili,Wang, Yufeng,Faraone, Stephen, V,Yan, Li,&Chang, Suhua.(2019).Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level.WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,20(6),476-485. |
MLA | Zhang, Kunlin,et al."Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level".WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 20.6(2019):476-485. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Genetic analysis for(1258KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论