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Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions
Zheng, Dang1,2,3; Chen, Jie2,4; Wang, Xiaoming1,2; Zhou, Yuan1,2,3,5
First AuthorZheng, Dang
2019-11-01
Source PublicationNEUROIMAGE
Correspondent Emailzhouyuan@psych.ac.cn (y. zhou)
ISSN1053-8119
Subtypearticle
Volume201Pages:11
Contribution Rank1
Abstract

Trait impulsivity, a predisposition to respond to stimuli without regard for the potentially negative consequences, contributes to many maladaptive behaviors. Studies have shown that both genetic factors and interregional functional interactions underlie trait impulsivity. However, whether common genes contribute to both trait impulsivity and its neural basis is still unknown. This study investigated the phenotypic correlations between trait impulsivity and the resting-state functional connectivity (rsFC) of the amygdala as well as its subregions and the genetic contribution to the phenotypic correlations. By recruiting a sample of 292 twins in late adolescence and young adulthood, we found that trait impulsivity was positively correlated with the rsFC between the left full amygdala and the right dorsolateral prefrontal cortex (DLPFC). Further analyses on the subregions of the amygdala showed that trait impulsivity was positively correlated with the rsFCs between the left basolateral (BL) amygdala and both the right DLPFC and the right inferior frontal gyrus and with the rsFCs between the right superficial (SF) amygdala and both the dorsal anterior cingulate cortex and right anterior insula. Bivariate genetic modelling analyses found genetic overlaps between trait impulsivity and the rsFC of the left full amygdala or the left BL amygdala with the right DLPFC. The proportions of phenotypic associations accounted for by overlapping genes were 82% and 60%, respectively. These results provide evidence for the genetic overlap between trait impulsivity and the intrinsic brain functional connectivity centered at the amygdala and especially at its BL subregion.

KeywordAmygdala Genetic correlation Resting-state functional connectivity Trait impulsivity Twin study
DOI10.1016/j.neuroimage.2019.07.010
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; CAS Key Laboratory of Behavioral Science, Institute of Psychology
Funding ProjectNational Natural Science Foundation of China[81771473] ; National Natural Science Foundation of China[91432302] ; National Natural Science Foundation of China[31300841] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2012075] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017119] ; CAS Key Laboratory of Behavioral Science, Institute of Psychology
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000487755700009
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordLINKED POLYMORPHIC REGION ; PREFRONTAL CORTEX ; ADOLESCENT BRAIN ; DECISION-MAKING ; PROMOTER POLYMORPHISM ; RESPONSE-INHIBITION ; PERSONALITY-TRAITS ; NEURAL BASIS ; HEAD MOTION ; EMOTION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30013
Collection中国科学院行为科学重点实验室
中国科学院心理健康重点实验室
Corresponding AuthorZhou, Yuan
Affiliation1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Dang,Chen, Jie,Wang, Xiaoming,et al. Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions[J]. NEUROIMAGE,2019,201:11.
APA Zheng, Dang,Chen, Jie,Wang, Xiaoming,&Zhou, Yuan.(2019).Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions.NEUROIMAGE,201,11.
MLA Zheng, Dang,et al."Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions".NEUROIMAGE 201(2019):11.
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