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Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions | |
Zheng, Dang1,2,3; Chen, Jie2,4![]() ![]() | |
First Author | Zheng, Dang |
Correspondent Email | zhouyuan@psych.ac.cn (y. zhou) |
Contribution Rank | 1 |
Abstract | Trait impulsivity, a predisposition to respond to stimuli without regard for the potentially negative consequences, contributes to many maladaptive behaviors. Studies have shown that both genetic factors and interregional functional interactions underlie trait impulsivity. However, whether common genes contribute to both trait impulsivity and its neural basis is still unknown. This study investigated the phenotypic correlations between trait impulsivity and the resting-state functional connectivity (rsFC) of the amygdala as well as its subregions and the genetic contribution to the phenotypic correlations. By recruiting a sample of 292 twins in late adolescence and young adulthood, we found that trait impulsivity was positively correlated with the rsFC between the left full amygdala and the right dorsolateral prefrontal cortex (DLPFC). Further analyses on the subregions of the amygdala showed that trait impulsivity was positively correlated with the rsFCs between the left basolateral (BL) amygdala and both the right DLPFC and the right inferior frontal gyrus and with the rsFCs between the right superficial (SF) amygdala and both the dorsal anterior cingulate cortex and right anterior insula. Bivariate genetic modelling analyses found genetic overlaps between trait impulsivity and the rsFC of the left full amygdala or the left BL amygdala with the right DLPFC. The proportions of phenotypic associations accounted for by overlapping genes were 82% and 60%, respectively. These results provide evidence for the genetic overlap between trait impulsivity and the intrinsic brain functional connectivity centered at the amygdala and especially at its BL subregion. |
Keyword | Amygdala Genetic correlation Resting-state functional connectivity Trait impulsivity Twin study |
2019-11-01 | |
Language | 英语 |
DOI | 10.1016/j.neuroimage.2019.07.010 |
Source Publication | NEUROIMAGE
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ISSN | 1053-8119 |
Volume | 201Pages:11 |
Subtype | article |
Indexed By | SCI |
Funding Project | National Natural Science Foundation of China[81771473] ; National Natural Science Foundation of China[91432302] ; National Natural Science Foundation of China[31300841] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2012075] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017119] ; CAS Key Laboratory of Behavioral Science, Institute of Psychology |
Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS Keyword | LINKED POLYMORPHIC REGION ; PREFRONTAL CORTEX ; ADOLESCENT BRAIN ; DECISION-MAKING ; PROMOTER POLYMORPHISM ; RESPONSE-INHIBITION ; PERSONALITY-TRAITS ; NEURAL BASIS ; HEAD MOTION ; EMOTION |
WOS Research Area | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS Subject | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS ID | WOS:000487755700009 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/30013 |
Collection | 中国科学院行为科学重点实验室 中国科学院心理健康重点实验室 |
Corresponding Author | Zhou, Yuan |
Affiliation | 1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China |
First Author Affilication | Key Laboratory of Behavioral Science, CAS; 管理支撑系统 |
Corresponding Author Affilication | Key Laboratory of Behavioral Science, CAS; 管理支撑系统 |
Recommended Citation GB/T 7714 | Zheng, Dang,Chen, Jie,Wang, Xiaoming,et al. Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions[J]. NEUROIMAGE,2019,201:11. |
APA | Zheng, Dang,Chen, Jie,Wang, Xiaoming,&Zhou, Yuan.(2019).Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions.NEUROIMAGE,201,11. |
MLA | Zheng, Dang,et al."Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions".NEUROIMAGE 201(2019):11. |
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