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Influence of comorbid anxiety symptoms on cognitive deficits in patients with major depressive disorder
Liu Jin1,2; Dong Qiangli1,2; Lu Xiaowen1,2; Sun Jinrong1,2; Zhang Liang1,2; Wang Mi1,2; Liu Bangshan1,2; Ju Yumeng1,2; Wan Ping3; Guo Hua3; Zhao Futao3; Zhang Xiangyang4; Zhang Yan1,2; Li Lingjiang1,2
First AuthorLiu Jin
Correspondent Emailzyddlove@1988.com (y. zhang) ; llj2920@163.com (l. li)
2020
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Subtypearticle
Volume260Pages:91-96
Contribution Rank4
Abstract

Background: Major depressive disorder (MDD) patients with comorbid anxiety symptoms showed obvious cognitive deficits. However, it remains unclear whether comorbid anxiety symptoms will make a specific contribution to cognitive deficits in MDD. Methods: Executive function, processing speed, attention and memory were assessed in 162 MDD patients, and 142 healthy controls (HCs) by a comprehensive neuropsychological battery. 14-item Hamilton Anxiety Rating Scale (HAM-A) was used for anxiety symptoms and MDD patients with HAM-A total score >14 were classified into MDD with comorbid anxiety (MDDA) group. A multivariate analysis of covariance and regression models was conducted to evaluate the effects of anxiety symptoms on cognitive deficits. Results: There were no significantly differences in all 4 cognitive domains between MDD alone and MDDA patients (all p < 0.05). In MDDA subgroup, HAM-A total score contributed to executive function and memory (both p < 0.05), while HAM-A psychic symptoms contributed to all 4 domains (all p < 0.05). Moreover, after controlling for the severity of depression, either anxiety symptoms shown as HAMA total score or psychic anxiety symptoms only contributed significantly to the executive function performance. Limitations: The cross-sectional design made it hard to acquire a cognitive performance trajectory accompanied by the fluctuations in anxiety symptoms. Conclusion: Our findings suggest that there is no significant difference in cognitive performance between MDD alone and MDDA patients. However, comorbid anxiety, especially psychic anxiety may contribute to extensive cognitive deficits in MDDA patients. Notably, anxiety symptoms only independently triggered executive dysfunction when eliminating effect of the severity of depression.

KeywordDepression Comorbid anxiety Cognitive function Executive function
DOI10.1016/j.jad.2019.08.091
Indexed BySCI
Language英语
Funding OrganizationNational Science and Technologic Program of China ; Defense Innovative Special Region Program ; National Natural Science Foundation of China
Funding ProjectNational Science and Technologic Program of China[2015BAI13B02] ; Defense Innovative Special Region Program[17-163-17-XZ-004-005-01] ; National Natural Science Foundation of China[81171286] ; National Natural Science Foundation of China[91232714] ; National Natural Science Foundation of China[81601180]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000490428300015
PublisherELSEVIER
WOS KeywordEXECUTIVE FUNCTION ; NEUROCOGNITIVE DEFICITS ; PERFORMANCE ; ATTENTION ; CONNECTIVITY ; METAANALYSIS ; IMPAIRMENT ; REMISSION ; HISTORY ; MEMORY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30143
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang Yan; Li Lingjiang
Affiliation1.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China
2.Cent S Univ, Mental Hlth Inst,Hunan Key Lab Psychiat & Mental, China Natl Clin Res Ctr Mental Disorders Xiangya, China Natl Technol Inst Mental Disorders,Hunan Te, Changsha 410011, Hunan, Peoples R China
3.Zhumadian Psychiat Hosp, Zhumadian 463000, Henan, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Liu Jin,Dong Qiangli,Lu Xiaowen,et al. Influence of comorbid anxiety symptoms on cognitive deficits in patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,260:91-96.
APA Liu Jin.,Dong Qiangli.,Lu Xiaowen.,Sun Jinrong.,Zhang Liang.,...&Li Lingjiang.(2020).Influence of comorbid anxiety symptoms on cognitive deficits in patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,260,91-96.
MLA Liu Jin,et al."Influence of comorbid anxiety symptoms on cognitive deficits in patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 260(2020):91-96.
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