Institutional Repository of Key Laboratory of Mental Health, CAS
Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder | |
Shen, Yanmei1,2; Wu, Fengchun3; Zhou, Yongjie4,5; Ma, Yuejiao1,2; Huang, Xingbing3; Ning, Yuping3; Lang, Xiaoe6; Luo, Xuerong1,2; Zhang, Xiangyang3,7,8 | |
第一作者 | Shen, Yanmei |
通讯作者邮箱 | luoxuerong@csu.edu.cn (x. luo) ; zhangxy@psych.ac.cn (x. zhang) |
心理所单位排序 | 7 |
摘要 | Backgrounds: Thyroid dysfunction was reported to be associated with depression; however, its role in suicide risk in patients with major depressive disorder (MDD) remains unclear. The objective of this study was to compare thyroid function between suicide attempters and non-suicide attempters in a large sample of first episode drug naive (FEDN) MDD patients, which received little systemic investigation. Methods: A total of 1718 outpatients with diagnosis of MDD at their first episode were recruited. Their sociodemographic, clinical data and thyroid function parameters were collected. The positive subscale of the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) were measured for psychotic, anxiety and depressive symptoms, respectively. Results: Our results showed that compared with non-suicide attempters, suicide attempters had greater scores on HAMD, HAMA and PANSS psychotic symptoms and higher serum levels in thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb) and thyroid peroxidases antibody (TPOAb) (all p < 0.001). Further logistic regression analysis indicated that suicide attempts were associated with severe anxiety with an adjusted odds ratio (OR) of 2.704 and TPOAb with an adjusted OR of 2.188. Limitations: No causal relationship could be drawn due to the cross-sectional design. Conclusions: Our results indicate TSH, TgAb and TPOAb may be promising biomarkers of suicide risk in MDD, suggesting the importance of regular assessment of thyroid function parameters for suicide prevention, and possible treatment for impaired thyroid function for intervention of suicide in MDD patients. |
关键词 | Depression Suicidal behavior Thyroid Anxiety Psychotic |
2019-12-01 | |
语种 | 英语 |
DOI | 10.1016/j.jad.2019.08.067 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 259页码:180-185 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81371477] |
出版者 | ELSEVIER |
WOS关键词 | CEREBROSPINAL-FLUID ; PHYSICAL ILLNESS ; THYROTROPIN ; HORMONE ; PEOPLE ; RISK ; METABOLITES ; BEHAVIORS ; PROLACTIN ; SEVERITY |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000489257500028 |
资助机构 | National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/30180 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Luo, Xuerong; Zhang, Xiangyang |
作者单位 | 1.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China 2.Cent S Univ, China Natl Technol Inst Mental Disorders, Mental Hlth Inst,China Natl Clin Res Ctr Mental D, Hunan Technol Inst Psychiat,Hunan Key Lab Psychia, Changsha 410011, Hunan, Peoples R China 3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China 4.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Hubei, Peoples R China 5.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Wuhan, Hubei, Peoples R China 6.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China 7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 8.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Shen, Yanmei,Wu, Fengchun,Zhou, Yongjie,et al. Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,259:180-185. |
APA | Shen, Yanmei.,Wu, Fengchun.,Zhou, Yongjie.,Ma, Yuejiao.,Huang, Xingbing.,...&Zhang, Xiangyang.(2019).Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,259,180-185. |
MLA | Shen, Yanmei,et al."Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 259(2019):180-185. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Association of thyro(256KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论