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Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder | |
Shen, Yanmei1,2; Wu, Fengchun3; Zhou, Yongjie4,5; Ma, Yuejiao1,2; Huang, Xingbing3; Ning, Yuping3; Lang, Xiaoe6; Luo, Xuerong1,2; Zhang, Xiangyang3,7,8![]() | |
First Author | Shen, Yanmei |
Correspondent Email | luoxuerong@csu.edu.cn (x. luo) ; zhangxy@psych.ac.cn (x. zhang) |
Contribution Rank | 7 |
Abstract | Backgrounds: Thyroid dysfunction was reported to be associated with depression; however, its role in suicide risk in patients with major depressive disorder (MDD) remains unclear. The objective of this study was to compare thyroid function between suicide attempters and non-suicide attempters in a large sample of first episode drug naive (FEDN) MDD patients, which received little systemic investigation. Methods: A total of 1718 outpatients with diagnosis of MDD at their first episode were recruited. Their sociodemographic, clinical data and thyroid function parameters were collected. The positive subscale of the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) were measured for psychotic, anxiety and depressive symptoms, respectively. Results: Our results showed that compared with non-suicide attempters, suicide attempters had greater scores on HAMD, HAMA and PANSS psychotic symptoms and higher serum levels in thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb) and thyroid peroxidases antibody (TPOAb) (all p < 0.001). Further logistic regression analysis indicated that suicide attempts were associated with severe anxiety with an adjusted odds ratio (OR) of 2.704 and TPOAb with an adjusted OR of 2.188. Limitations: No causal relationship could be drawn due to the cross-sectional design. Conclusions: Our results indicate TSH, TgAb and TPOAb may be promising biomarkers of suicide risk in MDD, suggesting the importance of regular assessment of thyroid function parameters for suicide prevention, and possible treatment for impaired thyroid function for intervention of suicide in MDD patients. |
Keyword | Depression Suicidal behavior Thyroid Anxiety Psychotic |
2019-12-01 | |
Language | 英语 |
DOI | 10.1016/j.jad.2019.08.067 |
Source Publication | JOURNAL OF AFFECTIVE DISORDERS
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ISSN | 0165-0327 |
Volume | 259Pages:180-185 |
Subtype | Article |
Indexed By | SCI |
Funding Project | National Natural Science Foundation of China[81371477] |
Publisher | ELSEVIER |
WOS Keyword | CEREBROSPINAL-FLUID ; PHYSICAL ILLNESS ; THYROTROPIN ; HORMONE ; PEOPLE ; RISK ; METABOLITES ; BEHAVIORS ; PROLACTIN ; SEVERITY |
WOS Research Area | Neurosciences & Neurology ; Psychiatry |
WOS Subject | Clinical Neurology ; Psychiatry |
WOS ID | WOS:000489257500028 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/30180 |
Collection | 中国科学院心理健康重点实验室 |
Corresponding Author | Luo, Xuerong; Zhang, Xiangyang |
Affiliation | 1.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China 2.Cent S Univ, China Natl Technol Inst Mental Disorders, Mental Hlth Inst,China Natl Clin Res Ctr Mental D, Hunan Technol Inst Psychiat,Hunan Key Lab Psychia, Changsha 410011, Hunan, Peoples R China 3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China 4.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Hubei, Peoples R China 5.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Wuhan, Hubei, Peoples R China 6.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China 7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 8.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China |
Corresponding Author Affilication | Key Laboratory of Mental Health, CAS |
Recommended Citation GB/T 7714 | Shen, Yanmei,Wu, Fengchun,Zhou, Yongjie,et al. Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,259:180-185. |
APA | Shen, Yanmei.,Wu, Fengchun.,Zhou, Yongjie.,Ma, Yuejiao.,Huang, Xingbing.,...&Zhang, Xiangyang.(2019).Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,259,180-185. |
MLA | Shen, Yanmei,et al."Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 259(2019):180-185. |
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