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Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder
Shen, Yanmei1,2; Wu, Fengchun3; Zhou, Yongjie4,5; Ma, Yuejiao1,2; Huang, Xingbing3; Ning, Yuping3; Lang, Xiaoe6; Luo, Xuerong1,2; Zhang, Xiangyang3,7,8
First AuthorShen, Yanmei
2019-12-01
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
Correspondent Emailluoxuerong@csu.edu.cn (x. luo) ; zhangxy@psych.ac.cn (x. zhang)
ISSN0165-0327
SubtypeArticle
Volume259Pages:180-185
Contribution Rank7
Abstract

Backgrounds: Thyroid dysfunction was reported to be associated with depression; however, its role in suicide risk in patients with major depressive disorder (MDD) remains unclear. The objective of this study was to compare thyroid function between suicide attempters and non-suicide attempters in a large sample of first episode drug naive (FEDN) MDD patients, which received little systemic investigation. Methods: A total of 1718 outpatients with diagnosis of MDD at their first episode were recruited. Their sociodemographic, clinical data and thyroid function parameters were collected. The positive subscale of the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) were measured for psychotic, anxiety and depressive symptoms, respectively. Results: Our results showed that compared with non-suicide attempters, suicide attempters had greater scores on HAMD, HAMA and PANSS psychotic symptoms and higher serum levels in thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb) and thyroid peroxidases antibody (TPOAb) (all p < 0.001). Further logistic regression analysis indicated that suicide attempts were associated with severe anxiety with an adjusted odds ratio (OR) of 2.704 and TPOAb with an adjusted OR of 2.188. Limitations: No causal relationship could be drawn due to the cross-sectional design. Conclusions: Our results indicate TSH, TgAb and TPOAb may be promising biomarkers of suicide risk in MDD, suggesting the importance of regular assessment of thyroid function parameters for suicide prevention, and possible treatment for impaired thyroid function for intervention of suicide in MDD patients.

KeywordDepression Suicidal behavior Thyroid Anxiety Psychotic
DOI10.1016/j.jad.2019.08.067
Indexed BySCI
Language英语
Funding OrganizationCAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China
Funding ProjectCAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China[81371477]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000489257500028
PublisherELSEVIER
WOS KeywordCEREBROSPINAL-FLUID ; PHYSICAL ILLNESS ; THYROTROPIN ; HORMONE ; PEOPLE ; RISK ; METABOLITES ; BEHAVIORS ; PROLACTIN ; SEVERITY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/30180
Collection中国科学院心理健康重点实验室
Corresponding AuthorLuo, Xuerong; Zhang, Xiangyang
Affiliation1.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China
2.Cent S Univ, China Natl Technol Inst Mental Disorders, Mental Hlth Inst,China Natl Clin Res Ctr Mental D, Hunan Technol Inst Psychiat,Hunan Key Lab Psychia, Changsha 410011, Hunan, Peoples R China
3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China
4.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Hubei, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Wuhan, Hubei, Peoples R China
6.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
8.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Shen, Yanmei,Wu, Fengchun,Zhou, Yongjie,et al. Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,259:180-185.
APA Shen, Yanmei.,Wu, Fengchun.,Zhou, Yongjie.,Ma, Yuejiao.,Huang, Xingbing.,...&Zhang, Xiangyang.(2019).Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,259,180-185.
MLA Shen, Yanmei,et al."Association of thyroid dysfunction with suicide attempts in first-episode and drug naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 259(2019):180-185.
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