With the help of techniques including behavioral study, electrophysiology, pharmacology, and functional brain imaging, the current project investigated the modulatory effect of depressive state on pain behaviors. It has been noticed that chronic pain and depression are comobidities. However, depressive patients often report lass experimental pain. To solve this contradiction, we imployed unpredictable chronic mild depression (UCMS) model for rodent depression, and described that UCMS rats displayed decreased sensitivity to radient heat pain, no matter in an acute condition or with the presense of complete Freud's adjuvant inflammation. However, these rats showed more pain behavior in the Formalin model. This indicate that depression inhibit noxious response to externally applied pain but enhance enternal persistant pain. To varify this conclusion, we use olfactory bombactomy animal, and find that this alternate depression model showed exactly the same effect on pain behavior. We further tested with hot plate, laser pulse, von Frey hair, and in the presense of L5 spinal nerve ligation, or tested the radient heat in Formalin rat model. All the results pointed to the same conclusion. Electrophysiological studies revealed decreased neuronal pain responses throughout the thalamocortical pain pathways, indicating a po
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