Recognizing Depression from the Microbiota-Gut-Brain Axis

doi:10.3390/ijms19061592

	Recognizing Depression from the Microbiota-Gut-Brain Axis
	Liang, Shan1 ; Wu, Xiaoli 1,2; Hu, Xu1 ; Wang, Tao1 ; Jin, Feng1
通讯作者	Jin, Feng(jinfeng@psych.ac.cn)
摘要	Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain-gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherapy. Unfortunately, most of the patients have never received any treatment. Studies indicate that gut microbiota could be a direct cause for the disorder. Abnormal microbiota and the microbiota-gut-brain dysfunction may cause mental disorders, while correcting these disturbance could alleviate depression. Nowadays, the gut microbiota modulation has become a hot topic in treatment research of mental disorders. Depression is closely related with the health condition of the brain-gut axis, and maintaining/restoring the normal condition of gut microbiota helps in the prevention/therapy of mental disorders.
关键词	major depressive disorder brain-gut axis microbiota-gut-brain axis gut microbiota psychobiotics
	2018-06-01
语种	英语
DOI	10.3390/ijms19061592
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1422-0067
卷号	19 期号:6 页码:16
收录类别	SCI
出版者	MDPI
WOS关键词	ADULT HIPPOCAMPAL NEUROGENESIS ; IRRITABLE-BOWEL-SYNDROME ; PITUITARY-ADRENAL AXIS ; CENTRAL-NERVOUS-SYSTEM ; FECAL MICROBIOTA ; MATERNAL SEPARATION ; MAJOR DEPRESSION ; INTESTINAL MICROBIOTA ; PSYCHIATRIC-DISORDERS ; PROBIOTIC TREATMENT
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000436506600047
引用统计	被引频次：159[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/30388
专题	中国科学院心理健康重点实验室
通讯作者	Jin, Feng
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Liang, Shan,Wu, Xiaoli,Hu, Xu,et al. Recognizing Depression from the Microbiota-Gut-Brain Axis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(6):16.
APA	Liang, Shan,Wu, Xiaoli,Hu, Xu,Wang, Tao,&Jin, Feng.(2018).Recognizing Depression from the Microbiota-Gut-Brain Axis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(6),16.
MLA	Liang, Shan,et al."Recognizing Depression from the Microbiota-Gut-Brain Axis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.6(2018):16.